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Oxytocin Receptor Polymorphisms are Differentially Associated with Social Abilities across Neurodevelopmental Disorders
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Oxytocin Receptor Polymorphisms are Differentially Associated with Social Abilities across Neurodevelopmental Disorders
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Journal Article
Oxytocin Receptor Polymorphisms are Differentially Associated with Social Abilities across Neurodevelopmental Disorders
2017
Overview
Oxytocin is a pituitary neuropeptide that affects social behaviour. Single nucleotide polymorphisms (SNPs) in the oxytocin receptor gene (
OXTR
) have been shown to explain some variability in social abilities in control populations. Whether these variants similarly contribute to the severity of social deficits experienced by children with neurodevelopmental disorders is unclear. Social abilities were assessed in a group of children with autism spectrum disorder (ASD, n = 341) or attention deficit hyperactivity disorder (ADHD, n = 276) using two established social measures. Scores were compared by
OXTR
genotype (rs53576, rs237887, rs13316193, rs2254298). Unexpectedly, the two most frequently studied
OXTR
SNPs in the general population (rs53576 and rs2254298) were associated with an increased severity of social deficits in ASD (p < 0.0001 and p = 0.0005), yet fewer social deficits in ADHD (p = 0.007 and p < 0.0001). We conclude that these genetic modifier alleles are not inherently risk-conferring with respect to their impact on social abilities; molecular investigations are greatly needed.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45/77
/ Alleles
/ Attention deficit hyperactivity disorder
/ Autism
/ Child
/ Children
/ Female
/ Genetic Predisposition to Disease
/ Genotype
/ Humanities and Social Sciences
/ Humans
/ Male
/ Neurodevelopmental disorders
/ Neurodevelopmental Disorders - diagnosis
/ Neurodevelopmental Disorders - genetics
/ Neurodevelopmental Disorders - psychology
/ Oxytocin
/ Polymorphism, Single Nucleotide
/ Receptors, Oxytocin - genetics
/ Science
