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Role of multidrug resistance-associated proteins in cancer therapeutics: past, present, and future perspectives
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Role of multidrug resistance-associated proteins in cancer therapeutics: past, present, and future perspectives
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Journal Article
Role of multidrug resistance-associated proteins in cancer therapeutics: past, present, and future perspectives
2021
Overview
Cancer, a major public health problem, is one of the world’s top leading causes of death. Common treatments for cancer include cytotoxic chemotherapy, surgery, targeted drugs, endocrine therapy, and immunotherapy. However, despite the outstanding achievements in cancer therapies during the last years, resistance to conventional chemotherapeutic agents and new targeted drugs is still the major challenge. In the present review, we explain the different mechanisms involved in cancer therapy and the detailed outlines of cancer drug resistance regarding multidrug resistance-associated proteins (MRPs) and their role in treatment failures by common chemotherapeutic agents. Further, different modulators of MRPs are presented. Finally, we outlined the models used to analyze MRP transporters and proposed a future impact that may set up a base or pave the way for many researchers to investigate the cancer MRP further.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Antineoplastic Agents - pharmacology
/ Cancer
/ death
/ Drugs
/ Earth and Environmental Science
/ Humans
/ Material requirements planning
/ Multidrug Resistance-Associated Proteins - pharmacology
/ Multidrug Resistance-Associated Proteins - therapeutic use
/ Multidrug resistant organisms
/ Proteins
/ surgery
