Asset Details
Do you wish to reserve the book?
Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a
Do you wish to request the book?
Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a
2020
Overview
CD300a receptor is found on different CD8+ T cell subsets and its expression has been associated to a more cytotoxic molecular signature. CD300a has an important role in some viral infections and its expression levels are known to be modulated by human immunodeficiency virus (HIV)−1 infection on several cell types. The main objective of this work was to investigate CD300a expression and its regulation during HIV-1 specific CD8+ T cell responses. CD300a receptor expression was analysed by multiparametric flow cytometry on CD8+ T lymphocytes from HIV negative donors, naive HIV-1+ individuals and HIV-1+ subjects under suppressive combined antiretroviral therapy (cART). HIV-1 specific CD8+ T cell response was studied by stimulating cells with HIV-1 derived peptides or with a Gag HIV-1 peptide. Our results showed that HIV-1 specific CD8+ T cells expressing higher levels of CD300a were more polyfunctional showing an increased degranulation and cytokine production. Moreover, we observed an up-regulation of CD300a expression after Gag HIV-1 peptide stimulation. Finally, our results demonstrated an inverse correlation between CD300a expression on CD8+ T lymphocytes and HIV disease progression markers. In conclusion, CD300a expression is associated to a better and more polyfunctional HIV-1 specific CD8+ T cell response.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 631/80
/ Anti-HIV Agents - therapeutic use
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - virology
/ HIV
/ HIV Infections - drug therapy
/ Human immunodeficiency virus
/ Humanities and Social Sciences
/ Humans
/ Peptides
/ Receptors, Immunologic - genetics
/ Receptors, Immunologic - metabolism
/ Science
