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FlySilico: Flux balance modeling of Drosophila larval growth and resource allocation
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FlySilico: Flux balance modeling of Drosophila larval growth and resource allocation
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Journal Article
FlySilico: Flux balance modeling of Drosophila larval growth and resource allocation
2019
Overview
Organisms depend on a highly connected and regulated network of biochemical reactions fueling life sustaining and growth promoting functions. While details of this metabolic network are well established, knowledge of the superordinate regulatory design principles is limited. Here, we investigated by iterative wet lab and modeling experiments the resource allocation process during the larval development of
Drosophila melanogaster
. We chose this system, as survival of the animals depends on the successful allocation of their available resources to the conflicting processes of growth and storage metabolite deposition. First, we generated “FlySilico”, a curated metabolic network of
Drosophila
, and performed time-resolved growth and metabolite measurements with larvae raised on a holidic diet. Subsequently, we performed flux balance analysis simulations and tested the predictive power of our model by simulating the impact of diet alterations on growth and metabolism. Our predictions correctly identified the essential amino acids as growth limiting factor, and metabolic flux differences in agreement with our experimental data. Thus, we present a framework to study important questions of resource allocation in a multicellular organism including process priorization and optimality principles.
Publisher
Nature Publishing Group UK,Nature Publishing Group
