Journal Article

A new alternative of a green polymeric matrix chitosan/alginate-polyethyleniminemethylene phosphonic acid for pharmaceutical residues adsorption

Merghache, Djamila, Meftah, Sara, Benbellil, Souheyla, Ferrah, Nacer

2022

Overview

A new generation of a green polymeric matrix, chitosan/alginate-polyethyleniminemethylene phosphonic acid (CHIT/ALG-PEIMPA) was examined in comparative study of adsorption and preconcentration of non-steroidal anti-inflammatory drugs (NSAIDs), diclofenac and ibuprofen. The influences of experimental parameters like pH, time reaction, initial concentration, ionic strength were investigated. The scanning electron microscopy (SEM) images showed heterogeneous morphology with different particle sizes of agglomerates from few micrometers to a hundred micrometers and irregular particles shape, before pharmaceuticals products adsorption. However, after adsorption, SEM micrograph reveals a smooth surface structure of agglomerate, and even in this smaller magnification, it was possible to observe the formation of homogenous and regular surface of CHIT/ALG-PEIMPA. Elementary analysis (EDX) reveals that the phosphonic acid (PEIMPA) was successfully cross-linked onto chitosan/alginate. The maximal adsorption capacity was found to be 222 mg.g −1 , and 122 mg.g −1 under optimum conditions for diclofenac and ibuprofen respectively. The kinetic modeling followed the pseudo-second-order rate expression for both pharmaceutical drugs. Thermodynamics data leads to an exothermic and spontaneous adsorption processes (∆ H = −34.32 KJ mol −1 ; ∆ H =−21.59 KJ mol −1 ), respectively for diclofenac and ibuprofen.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adsorption / Alginates / Alginic acid / Anti-inflammatory agents / Antibiotics / Aquatic Pollution / Atmospheric Protection/Air Quality Control/Air Pollution / Chitosan / Comparative studies / comparative study / crosslinking / Diclofenac / Earth and Environmental Science / Ecotoxicology / electron microscopy / Environment / Environmental Chemistry / Environmental Health / Environmental science / Exothermic reactions / heat production / Hydrogen-Ion Concentration / Ibuprofen / Inflammation / Ionic strength / Irregular particles / Kinetics / Micrography / Micrometers / Nonsteroidal anti-inflammatory drugs / Pharmaceutical Preparations / Pharmaceuticals / Phosphonic acids / phosphorous acid / Phosphorous Acids / Photomicrographs / polymers / Research Article / Scanning electron microscopy / Surface chemistry / Surface structure / Thermodynamics / Waste Water Technology / Water Management / Water Pollutants, Chemical / Water Pollution Control