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Calcium sulfate induced versus PMMA-induced membrane in a critical-sized femoral defect in a rat model
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Calcium sulfate induced versus PMMA-induced membrane in a critical-sized femoral defect in a rat model
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Calcium sulfate induced versus PMMA-induced membrane in a critical-sized femoral defect in a rat model
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Journal Article
Calcium sulfate induced versus PMMA-induced membrane in a critical-sized femoral defect in a rat model
2018
Overview
Aimed to investigate the characteristics of CS-induced membrane in comparison with the PMMA-induced membrane. Cellular components, histological changes, growth factor expressions of IL-6, VEGF, BMP-2, and TGF-β1 in the two induced membranes were compared at 2, 4, 6 and 8 weeks, respectively. We also compared the histological changes at the bone defects between CS and PMMA groups. The structural characteristics of induced membrane were similar between CS and PMMA. Endochondral ossification took place in the CS-induced membrane at 8 week. Levels of VEGF, BMP-2 and TGF-β1 in CS-induced membrane were insignificantly higher than those in PMMA-induced membrane at different time points. The expression of IL-6 was significantly higher in PMMA-induced membranes at 2nd week. In addition, osteogenic and neovascular activities of induced membranes increased with time and peaked at 6 weeks. CS promoted endochondral ossification at the broken ends of the bone defect than PMMA did. CS-induced membrane has a better capacity of generating VEGF, BMP-2 and TGF-β1.osteogenic and neovascular activities achieve highest level at 6 week. CS may have the potential to replace PMMA as a novel spacer in Masquelet technique.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/1
/ 13/21
/ 13/51
/ 59/78
/ 64
/ 82/1
/ 82/29
/ Animals
/ Bone morphogenetic protein 2
/ Bone Morphogenetic Protein 2 - genetics
/ Calcium Sulfate - pharmacology
/ Femoral Fractures - diagnostic imaging
/ Femoral Fractures - etiology
/ Femoral Fractures - genetics
/ Femur
/ Gene Expression Regulation - drug effects
/ Humanities and Social Sciences
/ Male
/ Polymethyl Methacrylate - pharmacology
/ Rats
/ Rodents
/ Science
/ Spacer
/ Transforming Growth Factor beta1 - genetics
/ Transforming growth factor-b1
/ Vascular endothelial growth factor
