Asset Details
Do you wish to reserve the book?
Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study
Do you wish to request the book?
Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study
2024
Overview
Study Objectives:
An estimated 3% of the population has clinically significant restless legs syndrome. Given the limited pharmacological options in the arsenal, there is a need for a therapeutic agent with a better side effect profile.
Methods:
Twelve treatment naive adults (10 women and 2 men with a median age of 41.5 [32–48.5] years) with primary restless legs syndrome were recruited in our open-label pilot study; magnesium citrate 200 mg was administered daily for 8 weeks. Serum magnesium levels, International Restless Legs Syndrome Study Group Rating Scale, Kohnen quality of life scale, and multiple suggested immobilization tests (three 1-hour tests) were performed before and after supplementation. Paired
t
tests and Wilcoxon signed-rank tests were used for data analysis. Pearson and Spearman’s analyses assessed the association between magnesium levels and restless legs syndrome variables.
Results:
Participants had a significant reduction in International Restless Legs Syndrome Study Group Rating Scale scores (6.67 [2.33–11]
P
= .006) and improved Kohnen quality of life scores (8.5 [2.09–14],
P
= .014) without notable differences in serum magnesium levels (
P
= .3). The median periodic limb movements during wakefulness index (30.40 [5.20, 122.40] to 8.63 [0.32, 17.47]
P
= .043) and self-reported discomfort score (19 [14, 30.5] to 6 [0, 8]
P
= .0010) of all 3 multiple suggested immobilization test trials also demonstrated improvement. Serum magnesium levels negatively correlated with multiple suggested immobilization test self-reported scores and the periodic limb movements during wakefulness indices.
Conclusions:
Despite the limitations of open-label design, our study’s positive results indicate the need for a placebo-controlled trial with a larger sample size.
Clinical Trial Registration:
Registry: ClinicalTrials.gov; Name: The Effect of Magnesium Citrate Supplementation in Restless Legs Syndrome (RLS); URL:
https://clinicaltrials.gov/ct2/show/study/NCT04462796
; Identifier: NCT04462796.
Citation:
Gorantla S, Ravisankar A, Trotti LM. Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study.
J Clin Sleep Med
. 2024;20(8):1357–1361.
Publisher
Springer International Publishing,Springer Nature B.V,American Academy of Sleep Medicine
Subject
