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Pulmonary immune profiling of SIDS: impaired immune maturation and age-related cytokine imbalance
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Pulmonary immune profiling of SIDS: impaired immune maturation and age-related cytokine imbalance
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Journal Article
Pulmonary immune profiling of SIDS: impaired immune maturation and age-related cytokine imbalance
2023
Overview
Background
For sudden infant death syndrome (SIDS), an impaired immunocompetence has been discussed for a long time. Cytokines and chemokines are soluble immune mediators (SIM) whose balance is essential for the immune status. We hypothesized that an imbalanced immune response might contribute to the etiology of SIDS.
Methods
We investigated 27 cytokines, chemokines, and growth factors in protein lysates of lungs derived from 29 SIDS cases and 15 control children deceased for other reasons.
Results
Except for the CCL5, no significant differences were detected in the lungs between SIDS cases with and without mild upper respiratory tract infections. In contrast, IL-1RA, IL-7, IL-13, and G-CSF were decreased in the merged SIDS cases compared to control cases without evidence of infection. Plotting SIM concentrations against infant age resulted in increasing concentrations in control but not in SIDS lungs, indicating a disturbed immune maturation. Moreover, an age-dependent shift towards a Th2-related pattern was observed in SIDS.
Conclusions
Our findings suggest that an impaired maturation of the immune system, an insufficient response to respiratory pathogens, and an immune response modulated by Th1/Th2 imbalance might play a possible role in triggering SIDS. These findings might in part be explained by chronic stress.
Impact
Maturation of the cytokine and chemokine network may be impaired in SIDS.
An imbalance between Th1- and Th2-related cytokines, which may reflect a state of chronic stress causing a more Th2 shift.
An impaired immune maturation, an insufficient response to respiratory pathogens, and an immune response modulated by Th1/Th2 imbalance might play a possible role in SIDS.
