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Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

by Wright, J. Fraser , Kalos, Michael , Levine, Bruce L , Grupp, Stephan A , Teachey, David T , Hauck, Bernd , Porter, David L , Chew, Anne , Aplenc, Richard , June, Carl H , Rheingold, Susan R , Barrett, David , Milone, Michael C

in Acute lymphoblastic leukemia / Antigens / Antigens, CD19 / Aplasia / Biological and medical sciences / Blast cells / Body weight / Bone marrow / CD19 antigen / Cerebrospinal fluid / Chemotherapy / Child / Children / Children & youth / Chimera / Chimeric antigen receptors / Chronic lymphocytic leukemia / Cytokines / Cytotoxicity / Etanercept / Female / Fever / General aspects / Hematologic and hematopoietic diseases / Humans / Immunotherapy / Laboratories / Leukemia / Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis / Lymphatic leukemia / Lymphocytes / Lymphocytes B / Lymphocytes T / Lymphoma / Medical sciences / Patients / Pediatrics / Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology / Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy / Receptors, Antigen, T-Cell / Remission / Remission Induction / T cell receptors / T-Lymphocytes - immunology / Tumor cells

2013

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Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

2013

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Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

2013

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Journal Article

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

Wright, J. Fraser,

Kalos, Michael,

Levine, Bruce L,

Grupp, Stephan A,

Teachey, David T,

Hauck, Bernd,

Porter, David L,

Chew, Anne,

Aplenc, Richard,

June, Carl H,

Rheingold, Susan R,

Barrett, David,

Milone, Michael C

2013

Overview

Chimeric antigen receptor–modified T cells have demonstrated efficacy in chronic lymphoid leukemia, an indolent disease. They have now been shown to have efficacy in two patients with rapidly progressive, treatment-refractory acute lymphoid leukemia. Patients with relapsed and chemotherapy-refractory pre–B-cell ALL have a poor prognosis despite the use of aggressive therapies such as allogeneic hematopoietic stem-cell transplantation 1 , 2 and bispecific CD19 antibody fragments. 3 Chimeric antigen receptor–modified T cells that target the lineage-specific antigens CD19 and CD20 have been reported to be effective in adults with CLL and B-cell lymphomas. 4 – 9 However, the effects of chimeric antigen receptor T cells on ALL blasts, a more immature leukemia that progresses more rapidly, have not been fully investigated. In particular, there has been uncertainty about whether chimeric antigen receptor T cells would expand in vivo in patients . . .

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Publisher

Massachusetts Medical Society

Subject

Acute lymphoblastic leukemia

/ Antigens

/ Antigens, CD19

/ Aplasia

/ Biological and medical sciences

/ Blast cells

/ Body weight