Journal Article

Assessing the optimal MRI descriptors to diagnose Ménière’s disease and the added value of analysing the vestibular aqueduct

McElroy, Sarah, Touska, Philip, Pai, Irumee, Connor, Steve, Hajnal, Joseph V., Ourselin, Sebastien

2024

Overview

Objectives To evaluate the diagnostic performance and reliability of MRI descriptors used for the detection of Ménière’s disease (MD) on delayed post-gadolinium MRI. To determine which combination of descriptors should be optimally applied and whether analysis of the vestibular aqueduct (VA) contributes to the diagnosis. Materials and methods This retrospective single centre case-control study evaluated delayed post-gadolinium MRI of patients with Ménièriform symptoms examined consecutively between Dec 2017 and March 2023. Two observers evaluated 17 MRI descriptors of MD and quantified perilymphatic enhancement (PLE) in the cochlea. Definite MD ears according to the 2015 Barany Society criteria were compared to control ears. Cohen’s kappa and diagnostic odds ratio (DORs) were calculated for each descriptor. Forward stepwise logistic regression determined which combination of MRI descriptors would best predict MD ears, and the area under the receiver operating characteristic curve for this model was measured. Results A total of 227 patients (mean age 48.3 ± 14.6, 99 men) with 96 definite MD and 78 control ears were evaluated. The presence of saccular abnormality (absent, as large as or confluent with the utricle) performed best with a DOR of 292.6 (95% confidence interval (CI), 38.305–2235.058). All VA descriptors demonstrated excellent reliability and with DORs of 7.761 (95% CI, 3.517–17.125) to 18.1 (95% CI, 8.445–39.170). Combining these saccular abnormalities with asymmetric cochlear PLE and an incompletely visualised VA correctly classified 90.2% of cases (sensitivity 84.4%, specificity 97.4%, AUC 0.938). Conclusion Either absent, enlarged or confluent saccules are the best predictors of MD. Incomplete visualisation of the VA adds value to the diagnosis. Clinical relevance statement A number of different MRI descriptors have been proposed for the diagnosis of Ménière’s disease, but by establishing the optimally performing MRI features and highlighting new useful descriptors, there is an opportunity to improve the diagnostic performance of Ménière’s disease imaging. Key Points • A comprehensive range of existing and novel vestibular aqueduct delayed post-gadolinium MRI descriptors were compared for their diagnostic performance in Ménière’s disease. • Saccular abnormality (absent, confluent with or larger than the utricle) is a reliable descriptor and is the optimal individual MRI predictor of Ménière’s disease. • The presence of this saccule descriptor or asymmetric perilymphatic enhancement and incomplete vestibular aqueduct visualisation will optimise the MRI diagnosis of Ménière’s disease.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Abnormalities / Adult / Asymmetry / Case-Control Studies / Cochlea / Confidence intervals / Contrast Media / Diagnosis / Diagnostic Radiology / Diagnostic systems / Ear / Ears & hearing / Female / Gadolinium / Head and Neck / Hearing loss / Hearing protection / Humans / Imaging / Internal Medicine / Interventional Radiology / Magnetic resonance imaging / Magnetic Resonance Imaging - methods / Male / Medicine / Medicine & Public Health / Meniere Disease - diagnostic imaging / Meniere's disease / Middle Aged / Neuroradiology / Optimization / Patients / Performance evaluation / Radiology / Regression models / Reliability / Reproducibility of Results / Retrospective Studies / Saccule / Sensitivity and Specificity / Statistical analysis / Ultrasound / Utricle / Vertigo / Vestibular Aqueduct - abnormalities / Vestibular Aqueduct - diagnostic imaging / Vestibular system / Visualization