Asset Details
Do you wish to reserve the book?
Autonomous mobile robots for exploratory synthetic chemistry
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Autonomous mobile robots for exploratory synthetic chemistry
Do you wish to request the book?
Autonomous mobile robots for exploratory synthetic chemistry
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Autonomous mobile robots for exploratory synthetic chemistry
2024
Overview
Autonomous laboratories can accelerate discoveries in chemical synthesis, but this requires automated measurements coupled with reliable decision-making
1
,
2
. Most autonomous laboratories involve bespoke automated equipment
3
–
6
, and reaction outcomes are often assessed using a single, hard-wired characterization technique
7
. Any decision-making algorithms
8
must then operate using this narrow range of characterization data
9
,
10
. By contrast, manual experiments tend to draw on a wider range of instruments to characterize reaction products, and decisions are rarely taken based on one measurement alone. Here we show that a synthesis laboratory can be integrated into an autonomous laboratory by using mobile robots
11
–
13
that operate equipment and make decisions in a human-like way. Our modular workflow combines mobile robots, an automated synthesis platform, a liquid chromatography–mass spectrometer and a benchtop nuclear magnetic resonance spectrometer. This allows robots to share existing laboratory equipment with human researchers without monopolizing it or requiring extensive redesign. A heuristic decision-maker processes the orthogonal measurement data, selecting successful reactions to take forward and automatically checking the reproducibility of any screening hits. We exemplify this approach in the three areas of structural diversification chemistry, supramolecular host–guest chemistry and photochemical synthesis. This strategy is particularly suited to exploratory chemistry that can yield multiple potential products, as for supramolecular assemblies, where we also extend the method to an autonomous function assay by evaluating host–guest binding properties.
A modular autonomous platform for general exploratory synthetic chemistry uses mobile robots to integrate an automated synthesis platform and two analysis platforms.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Chemistry Techniques, Synthetic - instrumentation
/ Chemistry Techniques, Synthetic - methods
/ Chromatography, Liquid - instrumentation
/ Chromatography, Liquid - methods
/ Humanities and Social Sciences
/ Magnetic Resonance Spectroscopy - instrumentation
/ Magnetic Resonance Spectroscopy - methods
/ Mass Spectrometry - instrumentation
/ NMR
/ Photochemistry - instrumentation
/ Redesign
/ Robots
/ Science
/ Workflow
