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KLHL40-related nemaline myopathy with a sustained, positive response to treatment with acetylcholinesterase inhibitors
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KLHL40-related nemaline myopathy with a sustained, positive response to treatment with acetylcholinesterase inhibitors
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Journal Article
KLHL40-related nemaline myopathy with a sustained, positive response to treatment with acetylcholinesterase inhibitors
2016
Overview
Congenital myopathies are a group of inherited muscle disorders characterized by hypotonia, weakness and a non-dystrophic muscle biopsy with the presence of one or more characteristic histological features. Neuromuscular transmission defects have recently been reported in several patients with congenital myopathies (CM). Mutations in
KLHL40
are among the most common causes of severe forms of nemaline myopathy. Clinical features of affected individuals include fetal akinesia or hypokinesia, respiratory failure, and swallowing difficulties at birth. Muscle weakness is usually severe and nearly half of the individuals have no spontaneous antigravity movement. The average age of death has been reported to be 5 months in a recent case series. Herein we present a case of a patient with a nemaline myopathy due to
KLHL40
mutations (c.604delG, p.Ala202Argfs*56 and c.1513G>C, p.Ala505Pro) with an impressive and prolonged beneficial response to treatment with high-dose pyridostigmine. Myasthenic features or response to ACEI have not previously been reported as a characteristic of nemaline myopathy or
KLHL40
-related myopathy.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Cholinesterase Inhibitors - therapeutic use
/ Female
/ Genes
/ Humans
/ Infant
/ Medicine
/ Muscle Proteins - metabolism
/ Muscle, Skeletal - metabolism
/ Muscle, Skeletal - pathology
/ Mutation
/ Myopathies, Nemaline - drug therapy
/ Myopathies, Nemaline - genetics
/ Myopathies, Nemaline - pathology
/ Patients
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