Asset Details
Do you wish to reserve the book?
From Dysbiosis to Distress: The Gut–Brain Connection in Trauma-Related Disorders
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
From Dysbiosis to Distress: The Gut–Brain Connection in Trauma-Related Disorders
Do you wish to request the book?
From Dysbiosis to Distress: The Gut–Brain Connection in Trauma-Related Disorders
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
From Dysbiosis to Distress: The Gut–Brain Connection in Trauma-Related Disorders
2026
Overview
Background: Post-traumatic stress disorder (PTSD) and trauma-related disorders are increasingly recognized as complex conditions involving not only psychological and neurobiological factors but also systemic physiological alterations. Among these, growing evidence points to the crucial role of the gut–brain axis in modulating stress responses, emotional regulation, and neuroinflammation. Objective: This narrative review aims to synthesize the emerging literature on the interactions between the gut microbiota and the central nervous system in PTSD and trauma-related disorders, highlighting potential mechanisms and therapeutic implications. Methods: A comprehensive search of the literature was conducted across PubMed and Scopus and Web of Science as primary bibliographic databases, focusing on clinical, preclinical, and translational studies published in the last two decades. Emphasis was placed on studies exploring the microbiota’s influence on neuroendocrine and immune pathways relevant to trauma, as well as intervention studies targeting the gut–brain axis. Results: Evidence suggests that dysbiosis and gut permeability alterations are associated with PTSD symptomatology, possibly via mechanisms involving hypothalamic–pituitary–adrenal (HPA) axis dysregulation, neuroinflammation, vagal signaling, and altered neurotransmitter production. Preclinical models support a bidirectional relationship between early-life stress, trauma, and gut microbiota alterations. Furthermore, preliminary clinical data indicate that interventions such as probiotics, diet modulation, and psychobiotics may exert beneficial effects on trauma-related psychopathology. Conclusions: The gut–brain axis represents a promising framework for understanding the pathophysiology of PTSD and related conditions. Although research is still in its early stages, targeting gut microbiota may offer novel preventive and therapeutic strategies. Further longitudinal and mechanistic studies are needed to validate these findings and guide clinical translation.
Publisher
MDPI AG,Multidisciplinary Digital Publishing Institute (MDPI)
Subject
/ Emotions
/ Gastrointestinal Microbiome - physiology
/ Hormones
/ Humans
/ Hypothalamo-Hypophyseal System - physiopathology
/ Microbiota (Symbiotic organisms)
/ Pituitary-Adrenal System - physiopathology
/ Post traumatic stress disorder
/ Review
/ Stress Disorders, Post-Traumatic - microbiology
/ Stress Disorders, Post-Traumatic - physiopathology
/ Stress Disorders, Post-Traumatic - psychology
/ Trauma
/ Trauma and Stressor Related Disorders - microbiology
