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Lutein acts via multiple antioxidant pathways in the photo-stressed retina
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Lutein acts via multiple antioxidant pathways in the photo-stressed retina
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Journal Article
Lutein acts via multiple antioxidant pathways in the photo-stressed retina
2016
Overview
Lutein slows the progression of age-related macular degeneration (AMD), a leading cause of blindness in ageing societies. However, the underlying mechanisms remain elusive. Here, we evaluated lutein’s effects on light-induced AMD-related pathological events. Balb/c mice exposed to light (2000 lux, 3 h) showed tight junction disruption in the retinal pigment epithelium (RPE) at 12 h, as detected by zona occludens-1 immunostaining. Substantial disruption remained 48 h after light exposure in the vehicle-treated group; however, this was ameliorated in the mice treated with intraperitoneal lutein at 12 h, suggesting that lutein promoted tight junction repair. In the photo-stressed RPE and the neighbouring choroid tissue, lutein suppressed reactive oxygen species and increased superoxide dismutase (SOD) activity at 24 h and produced sustained increases in
sod1
and
sod2
mRNA levels at 48 h. SOD activity was induced by lutein in an RPE cell line, ARPE19. We also found that lutein suppressed upregulation of macrophage-related markers,
f4/80
and
mcp-1
, in the RPE-choroid tissue at 18 h. In ARPE19, lutein reduced
mcp-1
mRNA levels. These findings indicated that lutein promoted tight junction repair and suppressed inflammation in photo-stressed mice, reducing local oxidative stress by direct scavenging and most likely by induction of endogenous antioxidant enzymes.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/106
/ 38
/ 38/77
/ 82
/ 82/1
/ 82/51
/ 96
/ Animals
/ Humanities and Social Sciences
/ Humans
/ Light
/ Macular Degeneration - drug therapy
/ Macular Degeneration - metabolism
/ Male
/ Mice
/ Oxidative Stress - drug effects
/ Reactive Oxygen Species - metabolism
/ Retinal Pigment Epithelium - drug effects
/ Retinal Pigment Epithelium - metabolism
/ Science
/ Superoxide Dismutase - metabolism
/ Superoxide Dismutase-1 - metabolism
/ Tight Junctions - drug effects
