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Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice
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Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice
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Journal Article
Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice
2016
Overview
Alterations in the gut microbiota play a crucial role in host physiology and metabolism; however, the molecular pathways underlying these changes in diet-induced obesity are unclear. Mechanistic target of rapamycin (mTOR) signaling pathway is associated with metabolic disorders such as obesity and type 2 diabetes (T2D). Therefore, we examined whether changes in the regulation of mTOR signaling induced by diet (a high-fat diet [HFD] or normal-chow diet) and/or therapeutics (resveratrol [a specific inhibitor of mTOR complex 1] or rapamycin [an inhibitor of both mTOR complex 1 and 2]) altered the composition of the gut microbiota in mice. Oral administration of resveratrol prevented glucose intolerance and fat accumulation in HFD-fed mice, whereas rapamycin significantly impaired glucose tolerance and exacerbated intestinal inflammation. The abundance of
Lactococcus
,
Clostridium
XI,
Oscillibacter
, and
Hydrogenoanaerobacterium
increased under the HFD condition; however, the abundance of these species declined after resveratrol treatment. Conversely, the abundance of unclassified
Marinilabiliaceae
and
Turicibacter
decreased in response to a HFD or rapamycin. Taken together, these results demonstrated that changes in the composition of intestinal microbiota induced by changes in mTOR activity correlate with obese and diabetic phenotypes.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 64/60
/ Animals
/ Bacteria - isolation & purification
/ Clostridium - isolation & purification
/ Gastrointestinal Microbiome - drug effects
/ Glucose Intolerance - prevention & control
/ Humanities and Social Sciences
/ Lactococcus - isolation & purification
/ Male
/ Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors
/ Mechanistic Target of Rapamycin Complex 1 - metabolism
/ Mechanistic Target of Rapamycin Complex 2 - antagonists & inhibitors
/ Mechanistic Target of Rapamycin Complex 2 - metabolism
/ Mice
/ Obesity - prevention & control
/ Science
