Journal Article

Impact of Alcohol and Coffee Intake on the Risk of Advanced Liver Fibrosis: A Longitudinal Analysis in HIV-HCV Coinfected Patients (ANRS CO-13 HEPAVIH Cohort)

Costa, Marie, Santos, Melina Erica, Esterle, Laure, Carrieri, Maria Patrizia, Protopopescu, Camelia, Wittkop, Linda, Gervais, Anne, Yaya, Issifou, Marcellin, Fabienne, Pialoux, Gilles, Salmon-Ceron, Dominique, Sogni, Philippe, Morlat, Philippe

2018

Overview

Background: Coffee intake has been shown to modulate both the effect of ethanol on serum GGT activities in some alcohol consumers and the risk of alcoholic cirrhosis in some patients with chronic diseases. This study aimed to analyze the impact of coffee intake and alcohol consumption on advanced liver fibrosis (ALF) in HIV-HCV co-infected patients. Methods: ANRS CO13-HEPAVIH is a French, nationwide, multicenter cohort of HIV-HCV-co-infected patients. Sociodemographic, behavioral, and clinical data including alcohol and coffee consumption were prospectively collected using annual self-administered questionnaires during five years of follow-up. Mixed logistic regression models were performed, relating coffee intake and alcohol consumption to ALF. Results: 1019 patients were included. At the last available visit, 5.8% reported high-risk alcohol consumption, 27.4% reported high coffee intake and 14.5% had ALF. Compared with patients with low coffee intake and high-risk alcohol consumption, patients with low coffee intake and low-risk alcohol consumption had a lower risk of ALF (aOR (95% CI) 0.24 (0.12–0.50)). In addition, patients with high coffee intake had a lower risk of ALF than the reference group (0.14 (0.03–0.64) in high-risk alcohol drinkers and 0.11 (0.05–0.25) in low-risk alcohol drinkers). Conclusions: High coffee intake was associated with a low risk of liver fibrosis even in HIV-HCV co-infected patients with high-risk alcohol consumption.

• Publisher: MDPI AG,MDPI
• Subject: Adult / alcohol drinking / Alcohol Drinking - adverse effects / Alcohol use / Biomarkers - blood / blood serum / chronic diseases / Coffee / Coffee - adverse effects / Cohort Studies / Consumption / Disease Progression / ethanol / Female / France - epidemiology / Health risk assessment / Hepatitis C, Chronic - blood / Hepatitis C, Chronic - complications / Hepatitis C, Chronic - virology / HIV Infections - blood / HIV Infections - complications / HIV Infections - virology / Humans / Life Sciences / Liver - physiopathology / Liver cirrhosis / Liver Cirrhosis - complications / Liver Cirrhosis - epidemiology / Liver Cirrhosis - etiology / Liver Cirrhosis - physiopathology / Longitudinal Studies / Male / Middle Aged / mixed infection / patients / Prospective Studies / questionnaires / regression analysis / Risk / Santé publique et épidémiologie / Self Report / Severity of Illness Index