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Lower-Dose Zinc for Childhood Diarrhea — A Randomized, Multicenter Trial

by Kumar, Jitendra , Manji, Karim , Somji, Sarah , Ashorn, Per , Bahl, Rajiv , Aboud, Said , Deb, Saikat , Chauhan, Aishwarya , Sazawal, Sunil , Bakari, Mohamed , Semwal, Om P , Sudfeld, Christopher R , Duggan, Christopher P , Dhingra, Usha , Dhingra, Pratibha , Devi, Prabhabati , Kisenge, Rodrick , Dutta, Arup , Liu, Enju , Simon, Jonathon

in Ambulatory care / Antidiarrheals - administration & dosage / Antidiarrheals - adverse effects / Antidiarrheals - blood / Caregivers / Child, Preschool / Childhood / Children / Clinical trials / Diarrhea / Diarrhea - drug therapy / Diarrhea, Infantile - drug therapy / Dosage / Dose-Response Relationship, Drug / Double-Blind Method / Enrollments / Ethics / Female / Health facilities / Humans / Illnesses / Infant / Male / Medication Adherence / Trace elements / Vomiting / Vomiting - chemically induced / Vomiting - epidemiology / Zinc / Zinc - administration & dosage / Zinc - adverse effects / Zinc - blood / Zinc sulfate

2020

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Lower-Dose Zinc for Childhood Diarrhea — A Randomized, Multicenter Trial

2020

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Lower-Dose Zinc for Childhood Diarrhea — A Randomized, Multicenter Trial

2020

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Journal Article

Lower-Dose Zinc for Childhood Diarrhea — A Randomized, Multicenter Trial

Kumar, Jitendra,

Manji, Karim,

Somji, Sarah,

Ashorn, Per,

Bahl, Rajiv,

Aboud, Said,

Deb, Saikat,

Chauhan, Aishwarya,

Sazawal, Sunil,

Bakari, Mohamed,

Semwal, Om P,

Sudfeld, Christopher R,

Duggan, Christopher P,

Dhingra, Usha,

Dhingra, Pratibha,

Devi, Prabhabati,

Kisenge, Rodrick,

Dutta, Arup,

Liu, Enju,

Simon, Jonathon

2020

Overview

Treatment with 20 mg of zinc daily for 10 to 14 days in children with acute diarrhea has been shown to improve diarrhea but increase vomiting. In this randomized trial involving children in Tanzania and India, 5 mg and 10 mg of daily zinc were noninferior to 20 mg of zinc for diarrhea and resulted in less vomiting.

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Publisher

Massachusetts Medical Society

Subject

Ambulatory care

/ Antidiarrheals - administration & dosage

/ Antidiarrheals - adverse effects

/ Antidiarrheals - blood

/ Caregivers

/ Child, Preschool

/ Childhood