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Teriparatide increases the maturation of circulating osteoblast precursors
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Journal Article
Teriparatide increases the maturation of circulating osteoblast precursors
2012
Overview
Summary
This study shows that teriparatide promotes the circulating osteoblast (OB) precursor degree of maturation in patients affected by postmenopausal osteoporosis.
Introduction
Anabolic treatment with teriparatide has proven effective for the therapy of postmenopausal osteoporosis and significantly reduces the risk of non-vertebral fragility fractures. The aim of this study was to investigate the effect of teriparatide on circulating OB precursors.
Methods
We evaluated by flow cytometry and real-time PCR the expression of OBs typical markers in peripheral blood mononuclear cells during treatment with teriparatide plus calcium and vitamin D, raloxifene plus calcium and vitamin D or calcium and vitamin D alone at various time points. Serum bone alkaline phosphatase and osteocalcin (OC) were measured as markers of bone turnover.
Results
Our results show that circulating OB precursors are more numerous and more immature in patients affected by fragility fractures than in osteoporotic patients without fractures. We also show that teriparatide treatment increases the expression of alkaline phosphatase and of OC in OB precursors; thus, it increases their degree of maturation.
Conclusions
We suggest that teriparatide acts as anabolic agents also by promoting the maturation of OB precursors.
Publisher
Springer-Verlag,Springer Nature B.V
Subject
/ Alkaline Phosphatase - blood
/ Bone Density Conservation Agents - pharmacology
/ Bone Density Conservation Agents - therapeutic use
/ Calcium
/ Cell Differentiation - drug effects
/ Female
/ Humans
/ Medicine
/ Mesenchymal Stromal Cells - drug effects
/ Osteoporosis, Postmenopausal - blood
/ Osteoporosis, Postmenopausal - complications
/ Osteoporosis, Postmenopausal - drug therapy
/ Osteoporotic Fractures - blood
/ Osteoporotic Fractures - etiology
/ Osteoporotic Fractures - prevention & control
/ Peripheral blood mononuclear cells
/ Raloxifene Hydrochloride - pharmacology
/ Raloxifene Hydrochloride - therapeutic use
