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A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation
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A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation
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Journal Article
A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation
2016
Overview
In this trial, long-term supplemental oxygen treatment did not result in longer survival than no use of supplemental oxygen among patients with stable COPD and moderate resting desaturation (Spo2, 89 to 93%) or moderate exercise-induced desaturation.
Two trials that were conducted in the 1970s showed that long-term treatment with supplemental oxygen reduced mortality among patients with chronic obstructive pulmonary disease (COPD) and severe resting hypoxemia.
1
,
2
These results led to the recommendation that supplemental oxygen be administered to patients with an oxyhemoglobin saturation, as measured by pulse oximetry (Spo
2
), of less than 89%.
3
,
4
In the 1990s, two trials evaluated long-term treatment with supplemental oxygen in patients with COPD who had mild-to-moderate daytime hypoxemia; neither trial showed a mortality benefit, but both were underpowered to assess mortality.
5
,
6
The effects of oxygen treatment on . . .
Publisher
Massachusetts Medical Society
Subject
/ Chronic obstructive pulmonary disease
/ Death
/ Female
/ Humans
/ Male
/ Oxygen
/ Oxygen Inhalation Therapy - adverse effects
/ Patients
/ Pulmonary Disease, Chronic Obstructive - blood
/ Pulmonary Disease, Chronic Obstructive - mortality
/ Pulmonary Disease, Chronic Obstructive - physiopathology
/ Pulmonary Disease, Chronic Obstructive - therapy
/ Sleep
