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Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin’s Lymphoma

by Lech-Maranda, Ewa , Liu, Rachael , Kim, Won S , Song, Eric , Illés, Árpád , Zinzani, Pier L , Jolin, Hina A , Jurczak, Wojciech , Alekseev, Sergey , Savage, Kerry J , Bartlett, Nancy L , Cunningham, David , Picardi, Marco , Smolewski, Piotr , Walewski, Jan , Oki, Yasuhiro , Ramchandren, Radhakrishnan , Straus, David J , Feldman, Tatyana , Josephson, Neil C , Younes, Anas , Radford, John , Gallamini, Andrea , Ansell, Stephen M , Rosta, Andras , Sachs, Jessica , Huebner, Dirk , Connors, Joseph M , Chen, Robert

in Adolescent / Adult / Aged / Aged, 80 and over / Antineoplastic Combined Chemotherapy Protocols - adverse effects / Antineoplastic Combined Chemotherapy Protocols - therapeutic use / Bleomycin / Bleomycin - administration & dosage / Brentuximab Vedotin / Cancer therapies / CD30 antigen / Chemotherapy / Clinical trials / Colony-stimulating factor / Dacarbazine / Dacarbazine - administration & dosage / Death / Disease prevention / Disease-Free Survival / Doxorubicin / Doxorubicin - administration & dosage / Drug dosages / Female / Follow-Up Studies / Granulocyte colony-stimulating factor / Hematology / Hodgkin Disease - drug therapy / Hodgkin Disease - mortality / Hodgkin's lymphoma / Humans / Immunoconjugates - administration & dosage / Immunoconjugates - adverse effects / Immunologic Factors - administration & dosage / Immunologic Factors - adverse effects / Immunotherapy / Leukocytes (granulocytic) / Lymphoma / Male / Medicine / Middle Aged / Monoclonal antibodies / Neoplasm Staging / Neutropenia / Neutropenia - chemically induced / Oncology / Peripheral neuropathy / Survival / Survival Rate / Targeted cancer therapy / Toxicity / Vinblastine / Vinblastine - administration & dosage / Young Adult

2018

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Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin’s Lymphoma

2018

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Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin’s Lymphoma

2018

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Journal Article

Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin’s Lymphoma

Lech-Maranda, Ewa,

Liu, Rachael,

Kim, Won S,

Song, Eric,

Illés, Árpád,

Zinzani, Pier L,

Jolin, Hina A,

Jurczak, Wojciech,

Alekseev, Sergey,

Savage, Kerry J,

Bartlett, Nancy L,

Cunningham, David,

Picardi, Marco,

Smolewski, Piotr,

Walewski, Jan,

Oki, Yasuhiro,

Ramchandren, Radhakrishnan,

Straus, David J,

Feldman, Tatyana,

Josephson, Neil C,

Younes, Anas,

Radford, John,

Gallamini, Andrea,

Ansell, Stephen M,

Rosta, Andras,

Sachs, Jessica,

Huebner, Dirk,

Connors, Joseph M,

Chen, Robert

2018

Overview

In a large randomized trial that compares regimens in which brentuximab vedotin replaced bleomycin, the group receiving the brentuximab had a 4.9 percentage-point improvement in modified progression-free survival, less pulmonary toxicity, and more myelotoxicity and neurotoxicity.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adult

/ Aged

/ Aged, 80 and over

/ Antineoplastic Combined Chemotherapy Protocols - adverse effects

/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use

/ Bleomycin