Journal Article

Neuropathic Pain: A Comprehensive Bibliometric Analysis of Research Trends, Contributions, and Future Directions

Pasqualucci, Alberto, Leoni, Matteo Luigi Giuseppe, Mercieri, Marco, Varrassi, Giustino, Cascella, Marco, Rekatsina, Martina, Viswanath, Omar, Caruso, Annalisa

2025

Overview

Background Neuropathic pain represents a significant public health concern due to its complex pathophysiology and the disability it can cause. Despite advancements in understanding its underlying mechanisms and potential treatments, challenges persist in achieving effective management. This bibliometric analysis aims to offer a comprehensive overview of research trends, key contributors, and existing gaps in the literature on neuropathic pain, providing valuable insights to guide future studies and enhance clinical approaches. Methods A bibliometric analysis was conducted using the Web of Science Core Collection (WoSCC) database. Key metrics, including publication trends, citation patterns, co-authorship networks, and keyword co-occurrence, were evaluated. Statistical analyses included average annual percentage change (APC) assessments and trend forecasting with an Auto Regressive Integrated Moving Average (ARIMA) model. Results A total of 9,974 studies published between 2005 and 2024 were included. Publications peaked between 2021 and 2022 but showed a slight decline thereafter, with forecasts predicting a steady increase from 2025 to 2030. Most papers were published in high-impact Q1 journals, reflecting the quality of research. Co-authorship analysis revealed central hubs of collaboration in the USA and China, with limited integration of smaller countries into the global research network. Keyword analysis identified multiple thematic clusters, including \"chronic pain,\" \"molecular mechanisms,\" and \"clinical management.\" Specific gaps were noted in understanding personalized therapeutic approaches, and non-pharmacological interventions. Conclusions This analysis underscores the critical need for continued research to address gaps in diagnosis, treatment, and management of neuropathic pain. Strengthening international collaborations and fostering multidisciplinary efforts will be pivotal in advancing this field.

• Publisher: Springer US,Springer Nature B.V
• Subject: Bibliometrics / Biomedical Research - trends / Co authorship / Humans / Internal Medicine / Medicine / Medicine & Public Health / Neuralgia - therapy / Neuropathic Pain (A Abd-Elsayed / Neuropathic Pain (A Abd-Elsayed, Section Editor) / Non-pharmacological intervention / Pain / Pain Medicine / Section Editor / Topical Collection on Neuropathic Pain / Trends