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Optical super-resolution histology of formalin-fixed paraffin-embedded tissue samples: challenges and opportunities
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Optical super-resolution histology of formalin-fixed paraffin-embedded tissue samples: challenges and opportunities
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Journal Article
Optical super-resolution histology of formalin-fixed paraffin-embedded tissue samples: challenges and opportunities
2025
Overview
This review covers the advancements of optical super-resolution microscopy (SRM) on formalin-fixed paraffin-embedded (FFPE) histological samples. We cover the implementation of various SRM strategies in histology, including wide field methods such as structured illumination microscopy, single-molecule localization microscopy and fluorescence fluctuations-based SRM, as well as the point-scanning stimulated emission depletion microscopy. We also cover the recent developments in FFPE-based expansion microscopy. The review highlights the advantages and challenges of these SRM methods in FFPE histology, and provides insights into emerging optical and computational techniques that can potentially open avenues for understanding disease mechanisms, tailoring treatments, and advancing personalized medicine across disciplines. This review article is intended for a broad audience, including histopathologists, biologists, physiologists, and physicists.
The review covers cutting-edge advancements in optical super-resolution microscopy (SRM) on formalin-fixed paraffin-embedded (FFPE) histological samples.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
