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Oral Nirmatrelvir–Ritonavir as Postexposure Prophylaxis for Covid-19

by Baniecki, Mary Lynn , Yunis, Carla , Wisemandle, Wayne , Rusnak, James M. , Luscan, Gerald , Kalfov, Veselin , Pypstra, Rienk , Hendrick, Victoria M. , Hammond, Jennifer , Burr, Aimee M. , Zhang, Wuyan , Fountaine, Robert J. , Soares, Holly

in Administration, Oral / Adult / Adverse events / Antigens / Antiretroviral drugs / Antiviral Agents - administration & dosage / Antiviral Agents - adverse effects / Antiviral Agents - therapeutic use / Antiviral drugs / Asymptomatic / Clinical trials / Coronavirus / Coronaviruses / COVID-19 / COVID-19 - prevention & control / COVID-19 Drug Treatment / COVID-19 vaccines / Disease prevention / Disease transmission / Double-Blind Method / Drug Combinations / Drug dosages / Drug Therapy, Combination / Female / Global Health / Households / Humans / Indazoles - adverse effects / Indazoles - therapeutic use / Indoles - administration & dosage / Indoles - adverse effects / Indoles - therapeutic use / Infections / Infectious Disease / Infectious Disease General / Lactams / Leucine / Male / Middle Aged / Nitriles / Original / Placebos / Polymerase chain reaction / Post-Exposure Prophylaxis / Proline / Risk factors / Ritonavir / Ritonavir - administration & dosage / Ritonavir - adverse effects / Ritonavir - therapeutic use / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Viral Infections / Young Adult

2024

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Oral Nirmatrelvir–Ritonavir as Postexposure Prophylaxis for Covid-19

2024

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2024

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Journal Article

Oral Nirmatrelvir–Ritonavir as Postexposure Prophylaxis for Covid-19

Baniecki, Mary Lynn,

Yunis, Carla,

Wisemandle, Wayne,

Rusnak, James M.,

Luscan, Gerald,

Kalfov, Veselin,

Pypstra, Rienk,

Hendrick, Victoria M.,

Hammond, Jennifer,

Burr, Aimee M.,

Zhang, Wuyan,

Fountaine, Robert J.,

Soares, Holly

2024

Overview

In this randomized trial, adults who had been exposed to a household contact with Covid-19 were given nirmatrelvir–ritonavir or placebo. Prophylaxis with nirmatrelvir–ritonavir did not prevent symptomatic Covid-19.

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Publisher

Massachusetts Medical Society

Subject

Administration, Oral

/ Adult

/ Adverse events

/ Antigens

/ Antiretroviral drugs

/ Antiviral Agents - administration & dosage

/ Antiviral Agents - adverse effects