Asset Details
Do you wish to reserve the book?
Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities
Do you wish to request the book?
Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities
2022
Overview
Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein that is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic reticulum stress and chondrocyte apoptosis, resulting in rare skeleton diseases. The bouquet-like structure of COMP allows it to act as a bridging molecule that regulates cellular phenotype and function. COMP is able to interact with many other ECM components and binds directly to a variety of cellular receptors and growth factors. The roles of COMP in other skeleton diseases, such as osteoarthritis, have been implied. As a well-established biochemical marker, COMP indicates cartilage turnover associated with destruction. Recent exciting achievements indicate its involvement in other diseases, such as malignancy, cardiovascular diseases, and tissue fibrosis. Here, we review the basic concepts of COMP and summarize its novel functions in the regulation of signaling events. These findings renew our understanding that COMP has a notable function in cell behavior and disease progression as a signaling regulator. Interestingly, COMP shows distinct functions in different diseases. Targeting COMP in malignancy may withdraw its beneficial effects on the vascular system and induce or aggravate cardiovascular diseases. COMP supplementation is a promising treatment for OA and aortic aneurysms while it may induce tissue fibrosis or cancer metastasis.
Publisher
MDPI AG,MDPI
Subject
/ Cardiovascular Diseases - metabolism
/ Cardiovascular Diseases - therapy
/ Cartilage Oligomeric Matrix Protein - genetics
/ Cartilage Oligomeric Matrix Protein - metabolism
/ Collagen
/ Disease
/ Extracellular Matrix Proteins - metabolism
/ Fibrosis
/ Humans
/ Matrilin Proteins - metabolism
/ Mutation
/ Proteins
/ Review
