Journal Article

Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis

Khashukoeva, Asiat Z., Tchepourina, Ekaterina, Chebysheva, Svetlana N., Geppe, Natalia A., Korsunskaya, Irina M., Evina, Olga E., Mezentsev, Alexandre, Sobolev, Vladimir V.

2022

Overview

The transcription factor FOSL1 plays an important role in cell differentiation and tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages, namely adipocytes, chondrocytes, and osteoblasts. In solid tumors, FOSL1 controls the progression of tumor cells through the epithelial–mesenchymal transformation. In this review, we summarize the available data on FOSL1 expression, stabilization, and degradation in the cell. We discuss how FOSL1 is integrated into the intracellular signaling mechanisms and provide a comprehensive analysis of FOSL1 influence on gene expression. We also analyze the pathological changes caused by altered Fosl1 expression in genetically modified mice. In addition, we dedicated a separate section of the review to the role of FOSL1 in human cancer. Primarily, we focus on the FOSL1 expression pattern in solid tumors, FOSL1 importance as a prognostic factor, and FOSL1 perspectives as a molecular target for anticancer therapy.

• Publisher: MDPI AG,MDPI
• Subject: Animals / Binding sites / Biosynthesis / Cancer / Carcinogenesis - genetics / Carcinogenesis - metabolism / Cell Differentiation / Cell Proliferation / Cytoplasm / Epithelial-Mesenchymal Transition / Gene expression / Gene Expression Regulation, Neoplastic / Humans / Kinases / Mice / Mutation / Phosphorylation / Protein Stability / Proteins / Proteolysis / Proto-Oncogene Proteins c-fos - chemistry / Proto-Oncogene Proteins c-fos - genetics / Proto-Oncogene Proteins c-fos - metabolism / Review / Transcription factors / Tumorigenesis