Journal Article

Vaccine for Prevention of Mild and Moderate-to-Severe Influenza in Children

Chanthavanich, Pornthep, Kerdpanich, Pirunghul, Yunus, Mohammed, Chandrasekaran, Vijayalakshmi, Kurugol, Zafer, Ceyhan, Mehmet, Caplanusi, Adrian, Alhan, Emre, Sirivichayakul, Chukiat, Quiambao, Beatriz P, Zaman, Khalequ, Rivera, Luis, Rivera-Medina, Doris M, Boutet, Philippe, Dinleyici, Ener C, Ofori-Anyinam, Opokua, Limkittikul, Kriengsak, Cravioto, Alejandro, Dbaibo, Ghassan, Durviaux, Serge, Innis, Bruce L, Espos, Roberto A, Jain, Varsha K

2013

Overview

In a multinational trial in children, a quadrivalent influenza vaccine (with both Victoria and Yamagata influenza B lineages, only one of which is included in the current trivalent vaccine) had about 59% efficacy. The incidence of influenza among children is high, and the illness is associated with substantial increases in outpatient visits and hospitalizations during the influenza season. 1 – 4 Routine vaccination of children against influenza is recommended in the United States 5 and some other countries, despite limited evidence of the efficacy of inactivated influenza vaccine from randomized, controlled trials involving children. 6 When trivalent influenza vaccines (TIVs) are used, there is a possibility of a mismatch between circulating and vaccine B strains, which results in inadequate protection from the vaccine. 7 – 10 A quadrivalent vaccine containing both B lineages would eliminate B-lineage mismatch. This may . . .

• Publisher: Massachusetts Medical Society
• Subject: Biological and medical sciences / Body temperature / Child / Child, Preschool / Children / Female / General aspects / Hemagglutination Inhibition Tests / Hepatitis A / Human viral diseases / Humans / Immunogenicity / Infectious diseases / Influenza / Influenza A / Influenza A virus - genetics / Influenza A virus - immunology / Influenza A virus - isolation & purification / Influenza B / Influenza B virus - genetics / Influenza B virus - immunology / Influenza B virus - isolation & purification / Influenza Vaccines - adverse effects / Influenza Vaccines - immunology / Influenza, Human - classification / Influenza, Human - diagnosis / Influenza, Human - immunology / Influenza, Human - prevention & control / Male / Medical sciences / Polymerase chain reaction / Proportional Hazards Models / Real-Time Polymerase Chain Reaction / Respiratory tract / Severity of Illness Index / Single-Blind Method / Vaccine efficacy / Vaccines / Vaccines, Inactivated - immunology / Viral diseases / Viral diseases of the respiratory system and ent viral diseases