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A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes

by Kollman, Craig C , Schoelwer, Melissa , Dokken, Betsy B , Ekhlaspour, Laya , Kanapka, Lauren G , Cengiz, Eda , Carria, Lori , Buckingham, Bruce A , Wadwa, R. Paul , DeBoer, Mark D , Breton, Marc D , Jost, Emily , Emory, Emma , Cherñavvsky, Daniel , Oliveri, Mary , Beck, Roy W , Forlenza, Gregory P , Ruedy, Katrina J , Hsu, Liana J , Weinzimer, Stuart A

in Adolescent / Age / Automation / Blood Glucose / Blood Glucose - analysis / Child / Children / Closed loop systems / Diabetes / Diabetes mellitus (insulin dependent) / Diabetes Mellitus, Type 1 / Diabetes Mellitus, Type 1 - blood / Diabetes Mellitus, Type 1 - drug therapy / Diabetic Ketoacidosis / Diabetic Ketoacidosis - etiology / FDA approval / Female / Glucose / Glycated Hemoglobin A / Glycated Hemoglobin A - analysis / Hemoglobin / Human health and pathology / Humans / Hypoglycemia / Hypoglycemia - chemically induced / Hypoglycemic Agents / Hypoglycemic Agents - administration & dosage / Hypoglycemic Agents - adverse effects / Infusion Pumps, Implantable / Injections, Subcutaneous / Insulin / Insulin - administration & dosage / Insulin - adverse effects / Insulin Infusion Systems / Insulin Infusion Systems - adverse effects / Ketoacidosis / Kidney diseases / Laboratories / Life Sciences / Male / Pancreas / Pancreas, Artificial / Patients / Quality of life / Statistical analysis

2020

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2020

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2020

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Journal Article

A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes

Kollman, Craig C,

Schoelwer, Melissa,

Dokken, Betsy B,

Ekhlaspour, Laya,

Kanapka, Lauren G,

Cengiz, Eda,

Carria, Lori,

Buckingham, Bruce A,

Wadwa, R. Paul,

DeBoer, Mark D,

Breton, Marc D,

Jost, Emily,

Emory, Emma,

Cherñavvsky, Daniel,

Oliveri, Mary,

Beck, Roy W,

Forlenza, Gregory P,

Ruedy, Katrina J,

Hsu, Liana J,

Weinzimer, Stuart A

2020

Overview

A closed-loop system (also called an artificial pancreas) may improve glycemic outcomes in children with type 1 diabetes. In this 16-week trial, the glucose level was in the target range for a greater percentage of time with a closed-loop system than with a sensor-augmented insulin pump.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Age

/ Automation

/ Blood Glucose

/ Blood Glucose - analysis

/ Child

/ Children