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Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
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Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
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Journal Article
Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
2013
Overview
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource, with potential for studying disease and use in regenerative medicine. However, genetic manipulation and technically challenging strategies such as nuclear transfer used in reprogramming limit their clinical applications. Here, we show that pluripotent stem cells can be generated from mouse somatic cells at a frequency up to 0.2% using a combination of seven small-molecule compounds. The chemically induced pluripotent stem cells resemble embryonic stem cells in terms of their gene expression profiles, epigenetic status, and potential for differentiation and germline transmission. By using small molecules, exogenous \"master genes\" are dispensable for cell fate reprogramming. This chemical reprogramming strategy has potential use in generating functional desirable cell types for clinical applications.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Cellular Reprogramming - drug effects
/ Cellular Reprogramming - genetics
/ Chimeras
/ Cloning
/ Drugs
/ Epithelial-Mesenchymal Transition - drug effects
/ Epithelial-Mesenchymal Transition - genetics
/ Genes
/ Green Fluorescent Proteins - genetics
/ Induced Pluripotent Stem Cells - cytology
/ Induced Pluripotent Stem Cells - metabolism
/ Mammals
/ medicine
/ Mice
/ Nuclei
/ Octamer Transcription Factor-3 - genetics
/ Octamer Transcription Factor-3 - metabolism
/ Online
/ oocytes
/ Promoter Regions, Genetic - drug effects
/ Rodents
/ Small Molecule Libraries - chemistry
