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Synthesis and Anticancer Evaluation of 4-Anilinoquinolinylchalcone Derivatives
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Synthesis and Anticancer Evaluation of 4-Anilinoquinolinylchalcone Derivatives
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Journal Article
Synthesis and Anticancer Evaluation of 4-Anilinoquinolinylchalcone Derivatives
2023
Overview
A series of 4-anilinoquinolinylchalcone derivatives were synthesized and evaluated for antiproliferative activities against the growth of human cancer cell lines (Huh-7 and MDA-MB-231) and normal lung cells (MRC-5). The results exhibited low cytotoxicity against human lung cells (MRC-5). Among them, (E)-3-4-[4-(benzyloxy)phenyl]aminoquinolin-2-yl-1-(4-methoxyphenyl) prop-2-en-1-one (4a) was found to have the highest cytotoxicity in breast cancer cells and low cytotoxicity in normal cells. Compound 4a causes ATP depletion and apoptosis of breast cancer MDA-MB-231 cells and triggers reactive oxygen species (ROS)-dependent caspase 3/7 activation. In conclusion, it is worth studying 4-anilinoquinolinylchalcone derivatives further as new potential anticancer agents for the treatment of human cancers.
Publisher
MDPI AG,MDPI
