Journal Article

Diabetes-Driven Atherosclerosis: Updated Mechanistic Insights and Novel Therapeutic Strategies

Patoulias, Dimitrios, Fragakis, Nikolaos, Theofilis, Panagiotis, Antoniadis, Antonios P., Vlachakis, Panayotis K., Karakasis, Paschalis

2025

Overview

The global rise in diabetes prevalence has significantly contributed to the increasing burden of atherosclerotic cardiovascular disease (ASCVD), a leading cause of morbidity and mortality in this population. Diabetes accelerates atherosclerosis through mechanisms such as hyperglycemia, oxidative stress, chronic inflammation, and epigenetic dysregulation, leading to unstable plaques and an elevated risk of cardiovascular events. Despite advancements in controlling traditional risk factors like dyslipidemia and hypertension, a considerable residual cardiovascular risk persists, highlighting the need for innovative therapeutic approaches. Emerging treatments, including sodium–glucose cotransporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, epigenetic modulators, and RNA-based therapies, are showing promise in addressing the unique challenges of diabetes-associated ASCVD. Precision medicine strategies, such as nanoparticle-based drug delivery and cell-specific therapies, offer further potential for mitigating cardiovascular complications. Advances in multiomics and systems biology continue to deepen our understanding of the molecular mechanisms driving diabetes-associated atherosclerosis. This review synthesizes recent advances in understanding the pathophysiology and treatment of diabetes-related atherosclerosis, offering a roadmap for future research and precision medicine approaches to mitigate cardiovascular risk in this growing population.

• Publisher: MDPI AG,MDPI
• Subject: Animals / Anticholesteremic agents / Antilipemic agents / Antioxidants / Atherosclerosis / Atherosclerosis - drug therapy / Atherosclerosis - etiology / Atherosclerosis - metabolism / Atherosclerosis - pathology / Atherosclerosis - therapy / Cardiovascular disease / Coronary vessels / Dapagliflozin / Development and progression / Dextrose / Diabetes / Diabetes Mellitus / Diabetes Mellitus, Type 2 - complications / Enzymes / Epigenetic inheritance / Epigenetics / Glucose / Health aspects / Heart attacks / Hemodynamics / Humans / Hyperglycemia / Hypertension / Inflammation / Kinases / Liraglutide / Liu, Timothy / Metabolism / Metabolites / Morphology / Nanoparticles / Nitric oxide / Oxidative stress / Pathogenesis / Precision Medicine / Proteins / Review / Risk factors / RNA / Shear stress / Sodium-Glucose Transporter 2 Inhibitors - therapeutic use / Transcription factors / Type 2 diabetes / Vein & artery diseases