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Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas

by Vergara-Alert, Júlia , Mykytyn, Anna Z. , Cantero, Guillermo , Haagmans, Bart L. , Segalés, Joaquim , Rodon, Jordi , Bosch, Berend-Jan , Brix, Alexander , Albulescu, Irina C. , Bensaid, Albert , Audonnet, Jean-Christophe

in Animal model / Animals / Antibodies / Camelid / Camelids / Coronaviruses / Disease transmission / Global health / Health risks / Immunization / Infections / Livestock / Llama / Medicine / Medicine & Public Health / MERS-CoV / Middle East respiratory syndrome / Middle East respiratory syndrome coronavirus / Multimeric protein scaffold particles (MPSP) / Proteins / Public Health / Respiratory diseases / Short Report / Vaccines

2022

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Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas

2022

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Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas

2022

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Journal Article

Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas

Vergara-Alert, Júlia,

Mykytyn, Anna Z.,

Cantero, Guillermo,

Haagmans, Bart L.,

Segalés, Joaquim,

Rodon, Jordi,

Bosch, Berend-Jan,

Brix, Alexander,

Albulescu, Irina C.,

Bensaid, Albert,

Audonnet, Jean-Christophe

2022

Overview

Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naïve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV.

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Publisher

BioMed Central,Springer Nature B.V,BMC

Subject

/ Animals

/ Camelid

/ Disease transmission