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Lithium Increases Serotonin Release and Decreases Serotonin Receptors in the Hippocampus
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Lithium Increases Serotonin Release and Decreases Serotonin Receptors in the Hippocampus
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Journal Article
Lithium Increases Serotonin Release and Decreases Serotonin Receptors in the Hippocampus
1981
Overview
The effects of long-term lithium administration on pre- and postsynaptic processes involved in serotonergic neurotransmission were measured in rat hippocampus and cerebral cortex. Long-term lithium administration increased both basal and potassium chloride-stimulated release of endogenous serotonin from the hippocampus but not from the cortex. Serotonergic receptor binding was reduced in the hippocampus but not in the cortex. These results suggest a mechanism by which lithium may stabilize serotonin neurotransmission.
Publisher
The American Association for the Advancement Science,American Association for the Advancement of Science
Subject
