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Physcomitrella patens, a versatile synthetic biology chassis
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Physcomitrella patens, a versatile synthetic biology chassis
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Journal Article
Physcomitrella patens, a versatile synthetic biology chassis
2018
Overview
Key message
During three decades the moss
Physcomitrella patens
has been developed to a superb green cell factory with the first commercial products on the market.
In the past three decades the moss
P. patens
has been developed from an obscure bryophyte to a model organism in basic biology, biotechnology, and synthetic biology. Some of the key features of this system include a wide range of Omics technologies, precise genome-engineering via homologous recombination with yeast-like efficiency, a certified good-manufacturing-practice production in bioreactors, successful upscaling to 500 L wave reactors, excellent homogeneity of protein products, superb product stability from batch-to-batch, and a reliable procedure for cryopreservation of cell lines in a master cell bank. About a dozen human proteins are being produced in
P. patens
as potential biopharmaceuticals, some of them are not only similar to their animal-produced counterparts, but are real biobetters with superior performance. A moss-made pharmaceutical successfully passed phase 1 clinical trials, a fragrant moss, and a cosmetic moss-product is already on the market, highlighting the economic potential of this synthetic biology chassis. Here, we focus on the features of mosses as versatile cell factories for synthetic biology and their impact on metabolic engineering.
