Journal Article

Influence of Hepatitis C Virus Infection on HIV-1 Disease Progression and Response to Highly Active Antiretroviral Therapy

Rockstroh, Jürgen K., Losso, Marcello H., Phillips, Andrew, Mocroft, Amanda, Soriano, Vincent, Horban, Andrzej, Tural, Cristina, Kirk, Ole, Lundgren, Jens, Ledergerber, Bruno

2005

Overview

ObjectiveTo assess hepatitis C virus (HCV) antibody prevalence in the EuroSIDA cohort, along with survival, human immunodeficiency virus (HIV)–1 disease progression, virologic response (plasma HIV-1 RNA load of <500 copies/mL), and CD4 cell count recovery by HCV serostatus in patients initiating highly active antiretroviral therapy (HAART) ResultsHCV serostatus at or before enrollment was available for 5957 patients; 1960 (33%) and 3997 (67%) were HCV seropositive and seronegative, respectively. No association between an increased incidence of acquired immunodeficiency syndrome-defining illnesses or death and HCV serostatus was seen after adjustment for other prognostic risk factors known at baseline (adjusted incidence rate ratio [IRR], 0.97 [95% confidence interval {CI}, 0.81–1.16]). However, there was a large increase in the incidence of liver disease–related deaths in HCV-seropositive patients in adjusted models (IRR, 11.71 [95% CI, 6.42–21.34]). Among 2260 patients of known HCV serostatus initiating HAART, after adjustment, there was no significant difference between HCV-seropositive and -seronegative patients with respect to virologic response (relative hazard [RH], 1.13 [95% CI, 0.84–1.51]) and immunologic response, whether measured as a ⩾50% increase (RH, 0.94 [95% CI, 0.77–1.16]) or a ⩾50 cells/μL increase (RH, 0.92 [95% CI, 0.77–1.11]) in CD4 cell count after HAART initiation ConclusionsHCV serostatus did not affect the risk of HIV-1 disease progression, but the risk of liver disease-related deaths was markedly increased in HCV-seropositive patients. The overall virologic and immunologic responses to HAART were not affected by HCV serostatus

• Publisher: The University of Chicago Press,University of Chicago Press,Oxford University Press
• Subject: Adult / AIDS / Anti-HIV Agents - therapeutic use / Antiretroviral Therapy, Highly Active / Biological and medical sciences / CD4 Lymphocyte Count / Cohort Studies / Coinfection / Disease Progression / Diseases / Female / Fundamental and applied biological sciences. Psychology / Hepacivirus / Hepatitis C - complications / Hepatitis C - immunology / Hepatitis C - mortality / Hepatitis C Antibodies - blood / Hepatitis C virus / Highly active antiretroviral therapy / HIV / HIV 1 / HIV Infections - complications / HIV Infections - drug therapy / HIV Infections - immunology / HIV Infections - virology / HIV-1 - isolation & purification / HIV/AIDS / Human immunodeficiency virus 1 / Human viral diseases / Humans / Infections / Infectious diseases / Liver / Male / Medical sciences / Microbiology / Middle Aged / Miscellaneous / Risk Factors / RNA / RNA, Viral - blood / Survival Analysis / Viral diseases / Viral diseases of the lymphoid tissue and the blood. Aids / Viral hepatitis / Virology