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IL-17-producing γδ T cells enhance bone regeneration
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Journal Article
IL-17-producing γδ T cells enhance bone regeneration
2016
Overview
Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that γδ T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a defect in osteoblastic bone formation. IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. This study identifies a novel role for IL-17-producing γδ T cells in skeletal tissue regeneration.
γδ T cells are innate-like lymphocytes that regulate immune responses by producing IL-17A or IFN-γ, but have no known role in bone healing. Here the authors show a nonimmune bone-regenerative function of IL-17A produced by the Vγ6+ subset in mice.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/106
/ 13/21
/ 13/31
/ 13/51
/ 38
/ 38/91
/ 64/60
/ 82
/ Animals
/ Bone Regeneration - immunology
/ Cell Differentiation - drug effects
/ Cell Differentiation - immunology
/ Femoral Fractures - immunology
/ Fracture Healing - immunology
/ Humanities and Social Sciences
/ Interleukin-17 - pharmacology
/ Mice
/ Receptors, Antigen, T-Cell, gamma-delta - genetics
/ Receptors, Antigen, T-Cell, gamma-delta - immunology
/ Reverse Transcriptase Polymerase Chain Reaction
/ Science
