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Adverse Health Outcomes in Women Exposed In Utero to Diethylstilbestrol
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Adverse Health Outcomes in Women Exposed In Utero to Diethylstilbestrol
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Journal Article
Adverse Health Outcomes in Women Exposed In Utero to Diethylstilbestrol
2011
Overview
This study, involving long-term follow-up of women exposed in utero to diethylstilbestrol (DES) and unexposed controls, showed increased risks of adverse reproductive outcomes, cervical intraepithelial neoplasia of grade 2 or higher, and breast cancer in women exposed to DES.
Soon after the first synthetic estrogen, diethylstilbestrol (DES), was developed in 1938,
1
it was used clinically to prevent complications of pregnancy.
2
In the early 1950s, four clinical trials revealed no evidence of efficacy, and DES use declined.
3
–
6
In the late 1960s, an unusual cluster of cases of clear-cell adenocarcinoma of the vagina and cervix in adolescent girls and young women was observed at one hospital.
7
The clinicians involved, working with the mothers of these women,
8
discovered a strong association between this cancer and in utero exposure to DES.
9
Subsequent clinical studies of women exposed to DES in utero showed . . .
Publisher
Massachusetts Medical Society
Subject
Adenocarcinoma, Clear Cell - chemically induced
/ Biological and medical sciences
/ Breast Neoplasms - chemically induced
/ Cancer
/ Cervical Intraepithelial Neoplasia - chemically induced
/ Cervix
/ Diethylstilbestrol - adverse effects
/ Estrogens, Non-Steroidal - adverse effects
/ Female
/ Genital Neoplasms, Female - chemically induced
/ Humans
/ Pregnancy Complications - chemically induced
/ Prenatal Exposure Delayed Effects
/ Vagina
