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IFN-γ decreases PD-1 in T lymphocytes from convalescent COVID-19 patients via the AKT/GSK3β signaling pathway

by Wang, Zhengxia , Shen, Weiyu , Xu, Tingting , Wu, Jingjing , Jiang, Jingxian , Zhang, Mingshun , Song, Meijuan , Liu, Yanan , Sun, Wei , Huang, Mao , Ji, Ningfei , Bian, Tao , Liu, Xiangqun

in 631/80/86/2371 / 692/699/255/2514 / AKT protein / Antibodies / Bioinformatics / CD8 antigen / CD8+ T cells / Convalescent patients / Coronavirus disease 2019 / COVID-19 / Critical care / Cytokine storm / Diabetes / Disease / Flow cytometry / Hospitals / Humanities and Social Sciences / IFN-γ / Immune status / Immune system / Infections / Long COVID / Lymphocytes / Lymphocytes T / Medicine / multidisciplinary / PD-1 / PD-1 protein / Science / Science (multidisciplinary) / Severe acute respiratory syndrome coronavirus 2 / Signal transduction / Viral infections / γ-Interferon

2024

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IFN-γ decreases PD-1 in T lymphocytes from convalescent COVID-19 patients via the AKT/GSK3β signaling pathway

by Wang, Zhengxia , Shen, Weiyu , Xu, Tingting , Wu, Jingjing , Jiang, Jingxian , Zhang, Mingshun , Song, Meijuan , Liu, Yanan , Sun, Wei , Huang, Mao , Ji, Ningfei , Bian, Tao , Liu, Xiangqun

2024

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IFN-γ decreases PD-1 in T lymphocytes from convalescent COVID-19 patients via the AKT/GSK3β signaling pathway

by Wang, Zhengxia , Shen, Weiyu , Xu, Tingting , Wu, Jingjing , Jiang, Jingxian , Zhang, Mingshun , Song, Meijuan , Liu, Yanan , Sun, Wei , Huang, Mao , Ji, Ningfei , Bian, Tao , Liu, Xiangqun

2024

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Journal Article

IFN-γ decreases PD-1 in T lymphocytes from convalescent COVID-19 patients via the AKT/GSK3β signaling pathway

Wang, Zhengxia,

Shen, Weiyu,

Xu, Tingting,

Wu, Jingjing,

Jiang, Jingxian,

Zhang, Mingshun,

Song, Meijuan,

Liu, Yanan,

Sun, Wei,

Huang, Mao,

Ji, Ningfei,

Bian, Tao,

Liu, Xiangqun

2024

Overview

Post-COVID-19 syndrome may be associated with the abnormal immune status. Compared with the unexposed age-matched elder group, PD-1 in the CD8 + T cells from recovered COVID-19 patients was significantly lower. IFN-γ in the plasma of COVID-19 convalescent patients was increased, which inhibited PD-1 expression in CD8 + T cells from COVID-19 convalescent patients. scRNA-seq bioinformatics analysis revealed that AKT/GSK3β may regulate the INF-γ/PD-1 axis in CD8 + T cells from COVID-19 convalescent patients. In parallel, an IFN-γ neutralizing antibody reduced AKT and increased GSK3β in PBMCs. An AKT agonist (SC79) significantly decreased p-GSK3β. Moreover, AKT decreased PD-1 on CD8 + T cells, and GSK3β increased PD-1 on CD8 + T cells according to flow cytometry analysis. Collectively, we demonstrated that recovered COVID-19 patients may develop long COVID. Increased IFN-γ in the plasma of recovered Wuhan COVID-19 patients contributed to PD-1 downregulation on CD8 + T cells by regulating the AKT/GSK3β signaling pathway.

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