Journal Article

Association between cardiovascular health and osteoporotic fractures: a national population-based study

Wang, Tingting, Ruan, Xiaorui, Ou, Jun, Wei, Jianhui, Sun, Mengting, Lei, Ridan, Qin, Jiabi

2025

Overview

Osteoporotic fractures are a major public health concern, particularly among the aging population, as they significantly contribute to morbidity, mortality, and reduced quality of life. While cardiovascular health (CVH) has traditionally been linked to cardiovascular disease outcomes, emerging evidence suggests it may also influence bone health. This study investigates the association between CVH, as measured by the Life’s Essential 8 (LE8) score, and the prevalence of osteoporotic fractures in U.S. adults. This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. A total of 17,606 adults aged 20 and above were included in the analysis after excluding participants with missing data on CVH or osteoporotic fractures. CVH was assessed using the LE8 score, which incorporates eight modifiable cardiovascular health metrics: diet, physical activity, tobacco use, sleep, body mass index (BMI), lipid levels, blood glucose, and blood pressure. The primary outcome, osteoporotic fractures, was identified through self-reported data confirmed by a physician. Weighted multivariate logistic regression models were used to estimate the association between CVH and the prevalence of osteoporotic fractures, adjusting for demographic and health-related covariates. Participants with higher CVH scores had a lower prevalence of osteoporotic fractures. In the fully adjusted model, each 1-point increase in the LE8 score was associated with a 1% reduction in the odds of osteoporotic fractures (OR = 0.99, 95% CI: 0.98–0.99). Compared to participants with low CVH levels, those with moderate CVH had a 22% lower odds of osteoporotic fractures (OR = 0.78, 95% CI 0.70–0.87), and those with high CVH had a 34% lower odds (OR = 0.66, 95% CI 0.56–0.79). A significant linear trend was observed across different CVH levels ( P for trend < 0.001). Subgroup analyses revealed that the inverse relationship between CVH and osteoporotic fractures was consistent across different demographic and health-related subgroups. This study highlights a significant inverse association between cardiovascular health and osteoporotic fractures in U.S. adults. These findings suggest that maintaining a high level of cardiovascular health, as measured by the LE8 score, may be important in reducing the risk of osteoporotic fractures. Public health strategies that integrate cardiovascular and bone health interventions may enhance overall health outcomes and reduce the societal burden of both cardiovascular diseases and osteoporosis.

• Publisher: Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
• Subject: 692/163 / 692/308 / 692/499 / 692/53 / 692/699 / Adult / Aged / Blood levels / Blood pressure / Body Mass Index / Bone / Cardiovascular diseases / Cardiovascular Diseases - complications / Cardiovascular Diseases - epidemiology / Cocoa / Cross-Sectional Studies / CVH / Demography / Female / Fractures / Health promotion / Humanities and Social Sciences / Humans / LE8 / Male / Middle Aged / Morbidity / multidisciplinary / NHANES / Nutrition / Nutrition Surveys / Osteoporosis / Osteoporotic fractures / Osteoporotic Fractures - epidemiology / Physical activity / Population studies / Population-based studies / Prevalence / Public health / Quality of life / Regression analysis / Risk Factors / Science / Science (multidisciplinary) / United States - epidemiology