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A Phase 1 Study of a Recombinant Viruslike Particle Vaccine against Human Papillomavirus Type 11 in Healthy Adult Volunteers
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A Phase 1 Study of a Recombinant Viruslike Particle Vaccine against Human Papillomavirus Type 11 in Healthy Adult Volunteers
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A Phase 1 Study of a Recombinant Viruslike Particle Vaccine against Human Papillomavirus Type 11 in Healthy Adult Volunteers
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Journal Article
A Phase 1 Study of a Recombinant Viruslike Particle Vaccine against Human Papillomavirus Type 11 in Healthy Adult Volunteers
2001
Overview
Viruslike particles (VLPs) produced from the L1 protein of several papillomaviruses have induced protection from infection after live challenge in animal models. In the present study, the safety and immunogenicity of a human papillomavirus (HPV)–11 L1 VLP candidate vaccine were measured in a phase 1, dose-finding trial in humans. The vaccine was well tolerated and induced high levels of both binding and neutralizing antibodies. Marked increases in lymphoproliferation to HPV-11 L1 antigens were noted after the second vaccination. In addition, lymphoproliferation was induced after vaccination in peripheral blood mononuclear cells (PBMC) stimulated with heterologous L1 VLP antigens of HPV types 6 and 16. Statistically significant increases in HPV antigen–specific interferon–γ and interleukin-5 production were measured from PBMC culture supernatants. This candidate HPV VLP vaccine induced robust B and T cell responses, and T cell helper epitopes appear to be conserved across HPV types
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
/ Adult
/ Antigens
/ Biological and medical sciences
/ Dosage
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Interferon-gamma - biosynthesis
/ Interleukin-5 - biosynthesis
/ Male
/ Oncogene Proteins, Viral - genetics
/ Oncogene Proteins, Viral - immunology
/ Placebos
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
/ Vaccines, DNA - adverse effects
/ Vaccines, DNA - pharmacology
/ Viral diseases of the lymphoid tissue and the blood. Aids
/ Viral Vaccines - adverse effects
/ Viral Vaccines - pharmacology
/ Virology
/ Viruses
