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Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B

by Tseng, J T , Lee, J-C , Wang, Y-C , Chang-Liao, P-Y , Lin, Y-J , Lee, C-T , Hung, L-Y , Yang, S-T , Chang, K-C , Tsou, J-H , Liu, Y-W , Lin, B-W

in 631/80/641/2187 / 631/80/82 / 692/420/755 / Antibodies / Aurora Kinase B - metabolism / Aurora Kinase C - genetics / Aurora Kinase C - metabolism / Biochemistry / Biomedical and Life Sciences / Cell Biology / Cell Culture / Cell Movement / Cell Proliferation / Cell Survival / Centromere - enzymology / Chromosomal Proteins, Non-Histone - metabolism / Dose-Response Relationship, Drug / Female / HeLa Cells / Histones - metabolism / Humans / Immunology / Inhibitor of Apoptosis Proteins - metabolism / Kinesin - metabolism / Life Sciences / M Phase Cell Cycle Checkpoints - drug effects / Neoplasm Invasiveness / Nocodazole - pharmacology / Original / original-article / Phosphorylation / Protein-Serine-Threonine Kinases - metabolism / Proteolysis / Spindle Apparatus - drug effects / Spindle Apparatus - enzymology / Time Factors / Transfection / Up-Regulation

2014

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Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B

by Tseng, J T , Lee, J-C , Wang, Y-C , Chang-Liao, P-Y , Lin, Y-J , Lee, C-T , Hung, L-Y , Yang, S-T , Chang, K-C , Tsou, J-H , Liu, Y-W , Lin, B-W

2014

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Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B

by Tseng, J T , Lee, J-C , Wang, Y-C , Chang-Liao, P-Y , Lin, Y-J , Lee, C-T , Hung, L-Y , Yang, S-T , Chang, K-C , Tsou, J-H , Liu, Y-W , Lin, B-W

2014

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Journal Article

Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B

Tseng, J T,

Lee, J-C,

Wang, Y-C,

Chang-Liao, P-Y,

Lin, Y-J,

Lee, C-T,

Hung, L-Y,

Yang, S-T,

Chang, K-C,

Tsou, J-H,

Liu, Y-W,

Lin, B-W

2014

Overview

The chromosomal passenger complex (CPC) plays a pivotal role in controlling accurate chromosome segregation and cytokinesis during cell division. Aurora-B, one of the chromosomal passenger proteins, is important for the mitotic spindle assembly checkpoint (SAC). Previous reports noted that Aurora-C is predominantly expressed in male germ cells and has the same subcellular localization as Aurora-B. Increasing evidence indicates that Aurora-C is overexpressed in many somatic cancers, although its function is uncertain. Our previous study showed that the aberrant expression of Aurora-C increases the tumorigenicity of cancer cells. Here, we demonstrate that overexpressed Aurora-C displaces the centromeric localization of CPCs, including INCENP, survivin, and Aurora-B. When cells were treated with nocodazole to turn on SAC, both the Aurora-B protein stability and kinase activity were affected by overexpressed Aurora-C. As a result, the activation of spindle checkpoint protein, BubR1, and phosphorylation of histone H3 and MCAK were also eliminated in Aurora-C-overexpressing cells. Thus, our results suggest that aberrantly expressed Aurora-C in somatic cancer cells may impair SAC by displacing the centromeric localization of CPCs.

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Publisher

Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group

Subject

/ Aurora Kinase B - metabolism

/ Aurora Kinase C - genetics

/ Aurora Kinase C - metabolism