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Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis

by Luis, Sushil A , Fang, Fang , Paolini, John F , Insalaco, Antonella , Klein, Allan L , Imazio, Massimo , Cremer, Paul , Brucato, Antonio , Pano, Arian , Wheeler, Alistair , Lewis, Basil S , Lin, David , Nicholls, Stephen J , LeWinter, Martin , Abbate, Antonio

in Adolescent / Adult / Adverse events / Aged / C-reactive protein / Clinical trials / Cytokines / Design / Double-Blind Method / Female / Humans / IL-1β / Inflammation / Injections, Subcutaneous - adverse effects / Interleukin 1 / Interleukin-1alpha / Interleukin-1beta / Male / Middle Aged / Pain / Patients / Pericarditis / Pericarditis - drug therapy / Pharmaceuticals / Placebos / Proportional Hazards Models / Receptors, Interleukin-1 Type I - antagonists & inhibitors / Recombinant Fusion Proteins - adverse effects / Recombinant Fusion Proteins - therapeutic use / Recurrence / Respiratory tract diseases / Respiratory Tract Infections - etiology / Young Adult

2021

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Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis

2021

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Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis

2021

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Journal Article

Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis

Luis, Sushil A,

Fang, Fang,

Paolini, John F,

Insalaco, Antonella,

Klein, Allan L,

Imazio, Massimo,

Cremer, Paul,

Brucato, Antonio,

Pano, Arian,

Wheeler, Alistair,

Lewis, Basil S,

Lin, David,

Nicholls, Stephen J,

LeWinter, Martin,

Abbate, Antonio

2021

Overview

Patients with recurrent pericarditis were treated with the interleukin-1 trap rilonacept. Those who had a response were randomly assigned to receive continued rilonacept or placebo. Rilonacept led to a significantly lower risk of pericarditis recurrence than placebo.

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Publisher

Massachusetts Medical Society

Subject

/ Adult

/ Aged