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Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa

by Molloy, Síle F , Karunaharan, Natasha , Temfack, Elvis , Ellis, Jayne , Chen, Tao , Lontsi, Sandrine , Lesikari, Sokoine , Mapoure, Yacouba N , Hosseinipour, Mina C , Kanyama, Cecilia , Lakhi, Shabir , Chawinga, Chimwemwe , Chanda, Duncan , Wang, Duolao , Lortholary, Olivier , Kalata, Newton , Jaffar, Shabbar , Bright, Philip , Kouanfack, Charles , Chan, Adrienne K , Stone, Neil , Gaskell, Kate , Lalloo, David G , Adams, Jack , van der Horst, Charles , van Oosterhout, Joep J , Peirse, Mary , Harrison, Thomas S , Bicanic, Tihana , Bradley, John , Sini, Victor , Mfinanga, Sayoki , Mwaba, Peter , Loyse, Angela , Heyderman, Robert S , Ndong, Jean-Gilbert , Lupiya, Duncan

in Administration, Oral / Adult / Africa - epidemiology / AIDS-Related Opportunistic Infections - drug therapy / Amphotericin B / Amphotericin B - administration & dosage / Amphotericin B - adverse effects / Antifungal agents / Antifungal Agents - adverse effects / Antifungal Agents - therapeutic use / Antigens / Arid zones / Body weight / Clinical trials / Drug Administration Schedule / Drug dosages / Drug Therapy, Combination / Fatalities / Female / Fluconazole / Fluconazole - administration & dosage / Fluconazole - adverse effects / Flucytosine / Flucytosine - administration & dosage / Flucytosine - adverse effects / Health risk assessment / HIV / HIV Seropositivity - complications / Human immunodeficiency virus / Humans / Induction therapy / Infections / Infectious diseases / Kaplan-Meier Estimate / Laboratories / Male / Medical research / Medicine / Meningitis / Meningitis, Cryptococcal - drug therapy / Meningitis, Cryptococcal - mortality / Mortality / Patients / Proportional Hazards Models / Teaching hospitals

2018

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2018

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2018

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Journal Article

Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa

Molloy, Síle F,

Karunaharan, Natasha,

Temfack, Elvis,

Ellis, Jayne,

Chen, Tao,

Lontsi, Sandrine,

Lesikari, Sokoine,

Mapoure, Yacouba N,

Hosseinipour, Mina C,

Kanyama, Cecilia,

Lakhi, Shabir,

Chawinga, Chimwemwe,

Chanda, Duncan,

Wang, Duolao,

Lortholary, Olivier,

Kalata, Newton,

Jaffar, Shabbar,

Bright, Philip,

Kouanfack, Charles,

Chan, Adrienne K,

Stone, Neil,

Gaskell, Kate,

Lalloo, David G,

Adams, Jack,

van der Horst, Charles,

van Oosterhout, Joep J,

Peirse, Mary,

Harrison, Thomas S,

Bicanic, Tihana,

Bradley, John,

Sini, Victor,

Mfinanga, Sayoki,

Mwaba, Peter,

Loyse, Angela,

Heyderman, Robert S,

Ndong, Jean-Gilbert,

Lupiya, Duncan

2018

Overview

Globally, cryptococcal meningitis is a leading cause of mortality among people with AIDS, despite the availability of effective amphotericin B–based therapy. In this trial in sub-Saharan Africa, the efficacy of two simpler treatment regimens was assessed.

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Publisher

Massachusetts Medical Society

Subject

Administration, Oral

/ Adult

/ Africa - epidemiology

/ Amphotericin B

/ Amphotericin B - administration & dosage

/ Amphotericin B - adverse effects

/ Antifungal agents