Journal Article

70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

Glas, Annuska M, Straehle, Carolyn, Rubio, Isabel T, Sotiriou, Christos, Brain, Etienne, Meulemans, Bart, van’t Veer, Laura J, Knox, Susan, Bogaerts, Jan, Slaets, Leen, Pierga, Jean-Yves, Goulioti, Theodora, Tryfonidis, Konstantinos, Bernards, René, Thompson, Alastair M, Matos, Erika, Nitz, Ulrike, Delaloge, Suzette, Viale, Giuseppe, Neijenhuis, Peter A, DeLorenzi, Mauro, Golfinopoulos, Vassilis, Causeret, Sylvain, Smilde, Tineke J, Vuylsteke, Peter, Saghatchian, Mahasti, Ravdin, Peter, Stork, Lisette, Cardoso, Fatima, Rutgers, Emiel, Piccart, Martine, Passalacqua, Rodolfo, Thomas, Geraldine, van der Hoeven, Jacobus M

2016

Overview

In a study in women with early breast cancer, those with high-risk clinical features and a low-risk gene-expression profile were assigned to chemotherapy or no chemotherapy. At 5 years, omission of chemotherapy led to a 1.5-percentage-point lower rate of survival without distant metastasis. Women with early-stage breast cancer are often treated with adjuvant systemic therapy consisting of chemotherapy, endocrine therapy, agents against human epidermal growth factor receptor 2 (HER2), or combinations of these drugs when appropriate. Treatment decisions are based on characteristics of the tumor (hormonal receptor and HER2 status, tumor grade and size, and lymph-node status) and of the patient (age, menopausal status, and performance status). 1 Tools that incorporate these features, such as Adjuvant! Online 2 , 3 and PREDICT Plus, 4 were created to assist in such decision making. However, these algorithms do not take into account the individual biologic characteristics of the patient’s . . .

• Publisher: Massachusetts Medical Society
• Subject: Adult / Aged / Antineoplastic Agents - therapeutic use / Breast cancer / Breast Neoplasms - drug therapy / Breast Neoplasms - genetics / Breast Neoplasms - mortality / Breast Neoplasms - surgery / Cancer therapies / Chemotherapy / Chemotherapy, Adjuvant / Clinical outcomes / Disease-Free Survival / Endocrine therapy / Epidermal growth factor / Female / Gene Expression / Gene Expression Profiling / Genetic Predisposition to Disease / Genetic Testing / Humans / Kaplan-Meier Estimate / Mastectomy / Metastases / Middle Aged / Neoplasm Metastasis - prevention & control / Neoplasm Staging / Oligonucleotide Array Sequence Analysis / Patients / Prospective Studies / Risk / Risk Assessment / Survival / Womens health