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Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction

by Mears, Sojaita Jenny , Aylward, Philip , Nicholls, Stephen J. , Gibson, C. Michael , Korjian, Serge , Lincoff, A. Michael , Heise, Mark , Tendera, Michal , Cornel, Jan H. , Alexander, John H. , Tricoci, Pierluigi , Trebacz, Jaroslaw , Lewis, Basil S. , Goodman, Shaun G. , Nicolau, Jose C. , Bode, Christoph , Bonaca, Marc , Deckelbaum, Lawrence I. , Parkhomenko, Alexander , Bhatt, Deepak L. , Sacks, Frank M. , Povsic, Thomas J. , Kastelein, John J.P. , Libby, Peter , Duffy, Danielle , Bahit, M. Cecilia , Steg, P. Gabriel , Chi, Gerald , Harrington, Robert A. , Mahaffey, Kenneth W. , Lopes, Renato D. , Ridker, Paul M. , Pocock, Stuart J. , Merkely, Bela , Mehran, Roxana

in Acute Coronary Syndromes / Aged / Apolipoprotein A-I - administration & dosage / Apolipoprotein A-I - blood / Apolipoproteins / Atherosclerosis / Cardiology / Cardiovascular disease / Cardiovascular diseases / Cardiovascular Diseases - etiology / Cardiovascular Diseases - metabolism / Cardiovascular Diseases - mortality / Cardiovascular Diseases - prevention & control / Cerebral infarction / Cholesterol / Clinical Medicine / Clinical Medicine General / Coronary artery disease / Coronary Artery Disease - complications / Coronary Artery Disease - drug therapy / Coronary Disease / Coronary vessels / Diabetes / Double-Blind Method / Emergency Medicine / Emergency Medicine General / Female / Heart attacks / Heart diseases / High density lipoprotein / Humans / Hypothesis testing / Infusions, Intravenous / Ischemia / Kaplan-Meier Estimate / Lipids / Lipoproteins, HDL - blood / Lipoproteins, HDL - metabolism / Male / Middle Aged / Myocardial Infarction / Myocardial Infarction - complications / Myocardial Infarction - drug therapy / Myocardial Infarction - metabolism / Myocardial Infarction - mortality / Placebos / Recurrence / Risk Factors / Secondary Prevention / Statistical analysis / Stroke / Stroke - prevention & control / Vein & artery diseases

2024

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Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction

2024

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2024

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Journal Article

Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction

Mears, Sojaita Jenny,

Aylward, Philip,

Nicholls, Stephen J.,

Gibson, C. Michael,

Korjian, Serge,

Lincoff, A. Michael,

Heise, Mark,

Tendera, Michal,

Cornel, Jan H.,

Alexander, John H.,

Tricoci, Pierluigi,

Trebacz, Jaroslaw,

Lewis, Basil S.,

Goodman, Shaun G.,

Nicolau, Jose C.,

Bode, Christoph,

Bonaca, Marc,

Deckelbaum, Lawrence I.,

Parkhomenko, Alexander,

Bhatt, Deepak L.,

Sacks, Frank M.,

Povsic, Thomas J.,

Kastelein, John J.P.,

Libby, Peter,

Duffy, Danielle,

Bahit, M. Cecilia,

Steg, P. Gabriel,

Chi, Gerald,

Harrington, Robert A.,

Mahaffey, Kenneth W.,

Lopes, Renato D.,

Ridker, Paul M.,

Pocock, Stuart J.,

Merkely, Bela,

Mehran, Roxana

2024

Overview

In patients with acute MI, multivessel coronary artery disease, and other cardiovascular risk factors, CSL112 (human plasma–derived apolipoprotein A1) did not reduce the risk of MI, stroke, or death from cardiovascular causes.

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Publisher

Massachusetts Medical Society

Subject

Acute Coronary Syndromes

/ Aged

/ Apolipoprotein A-I - administration & dosage

/ Apolipoprotein A-I - blood

/ Apolipoproteins

/ Atherosclerosis

/ Cardiology