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Long-Acting Cabotegravir and Rilpivirine after Oral Induction for HIV-1 Infection

by Walmsley, Sharon , Ford, Susan L , Pokrovsky, Vadim , Cutrell, Amy , Patel, Parul , Girard, Pierre-Marie , Bettacchi, Chris , Williams, Peter E , Overton, Edgar T , Orkin, Chloe , Vanveggel, Simon , Lombaard, Johan , Griffith, Sandy , Arasteh, Keikawus , Smith, Kimberly Y , St. Clair, Marty , Brinson, Cynthia , Dorey, David , Margolis, David A , Chounta, Vasiliki , Spreen, William R , D’Amico, Ronald , Górgolas Hernández-Mora, Miguel , Oka, Shinichi , Philibert, Patrick , Crauwels, Herta , Parys, Wim

in Abacavir / Administration, Oral / Adult / Algorithms / Anti-HIV Agents - administration & dosage / Anti-HIV Agents - adverse effects / Anti-HIV Agents - blood / Anti-Retroviral Agents - therapeutic use / Antiretroviral drugs / Antiretroviral therapy / CD4 Lymphocyte Count / Drug dosages / Drug Resistance, Viral - genetics / Drug therapy / Drug Therapy, Combination / FDA approval / Female / HIV / HIV Infections - drug therapy / HIV-1 - genetics / HIV-1 - isolation & purification / Human immunodeficiency virus / Humans / Induction Chemotherapy / Induction therapy / Injection / Injections, Intramuscular / Lamivudine / Maintenance Chemotherapy / Male / Middle Aged / Mutation / Patient Reported Outcome Measures / Plasma / Pyridones - administration & dosage / Pyridones - adverse effects / Pyridones - blood / Ribonucleic acid / Rilpivirine - administration & dosage / Rilpivirine - adverse effects / Rilpivirine - blood / RNA / RNA, Viral - blood / Viral Load

2020

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Long-Acting Cabotegravir and Rilpivirine after Oral Induction for HIV-1 Infection

2020

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Long-Acting Cabotegravir and Rilpivirine after Oral Induction for HIV-1 Infection

2020

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Journal Article

Long-Acting Cabotegravir and Rilpivirine after Oral Induction for HIV-1 Infection

Walmsley, Sharon,

Ford, Susan L,

Pokrovsky, Vadim,

Cutrell, Amy,

Patel, Parul,

Girard, Pierre-Marie,

Bettacchi, Chris,

Williams, Peter E,

Overton, Edgar T,

Orkin, Chloe,

Vanveggel, Simon,

Lombaard, Johan,

Griffith, Sandy,

Arasteh, Keikawus,

Smith, Kimberly Y,

St. Clair, Marty,

Brinson, Cynthia,

Dorey, David,

Margolis, David A,

Chounta, Vasiliki,

Spreen, William R,

D’Amico, Ronald,

Górgolas Hernández-Mora, Miguel,

Oka, Shinichi,

Philibert, Patrick,

Crauwels, Herta,

Parys, Wim

2020

Overview

Simplified treatment regimens for HIV-1 may have advantages. In this open-label, randomized, controlled trial, patients with HIV-1 infection who had not previously received antiretroviral therapy were given oral induction therapy, then treated with either monthly injections of long-acting cabotegravir and rilpivirine or standard treatment. At 48 weeks, similar viral suppression was observed with the two regimens.

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Publisher

Massachusetts Medical Society

Subject

Abacavir

/ Administration, Oral

/ Adult

/ Algorithms

/ Anti-HIV Agents - administration & dosage

/ Anti-HIV Agents - adverse effects

/ Anti-HIV Agents - blood