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Relationship of Post-Transplant Lymphoproliferative Disorders (PTLD) Subtypes and Clinical Outcome in Pediatric Heart Transplant Recipients: A Retrospective Single Institutional Analysis/Experience of 558 Patients

by Liu, Yan , Chinnock, Richard , Chau, Peter , Wang, Billy C. , Wang, Jun , Zuppan, Craig W. , Fitts, James

in Age / Children / Classification / Diagnosis / Epstein-Barr virus / Heart / Heart transplantation / Heart transplants / Hodgkin's lymphoma / Hyperplasia / Immunoproliferative diseases / Immunosuppression / Infants / Infections / Lymphocytes / Lymphoma / Lymphoproliferative disorders / Mononucleosis / Patient outcomes / Patients / Pediatric research / Pediatrics / Posttransplant lymphoproliferative disorders / Risk factors / Statistical significance / Surgery / Survival / Transplantation / Tumors

2023

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by Liu, Yan , Chinnock, Richard , Chau, Peter , Wang, Billy C. , Wang, Jun , Zuppan, Craig W. , Fitts, James

2023

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by Liu, Yan , Chinnock, Richard , Chau, Peter , Wang, Billy C. , Wang, Jun , Zuppan, Craig W. , Fitts, James

2023

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Journal Article

Relationship of Post-Transplant Lymphoproliferative Disorders (PTLD) Subtypes and Clinical Outcome in Pediatric Heart Transplant Recipients: A Retrospective Single Institutional Analysis/Experience of 558 Patients

Liu, Yan,

Chinnock, Richard,

Chau, Peter,

Wang, Billy C.,

Wang, Jun,

Zuppan, Craig W.,

Fitts, James

2023

Overview

Post-transplant lymphoproliferative disorders (PTLD) are heterogenous lymphoproliferative disorders that develop as a consequence of immunosuppression in transplant recipients. We sought to determine if subtypes of PTLD correlated with different outcomes. We performed a retrospective review of PTLD occurring in pediatric heart transplant recipients. A total of 558 children and infants underwent cardiac transplantation at our institution between 1985 and 2019 and were followed until March 2021. Forty-nine of 558 patients developed PTLD (8.8%). As compared to older children (>one year of age), infant recipients (

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Publisher

MDPI AG,MDPI

Subject

/ Heart

/ Heart transplantation