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The transcriptional and signalling networks of pluripotency
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Journal Article
The transcriptional and signalling networks of pluripotency
2011
Overview
Pluripotency and self-renewal are the hallmarks of embryonic stem cells. This state is maintained by a network of transcription factors and is influenced by specific signalling pathways. Current evidence indicates that multiple pluripotent states can exist
in vitro
. Here we review the recent advances in studying the transcriptional regulatory networks that define pluripotency, and elaborate on how manipulation of signalling pathways can modulate pluripotent states to varying degrees.
Publisher
Nature Publishing Group UK,Nature Publishing Group
