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Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs
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Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs
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Journal Article
Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs
2019
Overview
Tissue-resident memory CD8
T (T
) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection. CD8
T
cells within the skin and the small intestine are long-lived and maintained independently of circulating memory CD8
T cells. In contrast to CD8
T
cells at these sites, CD8
T
cells that arise after influenza virus infection within the lungs display high turnover and require constant recruitment from the circulating memory pool for long-term persistence. The distinct characteristics of CD8
T
cell maintenance within the lungs may suggest a unique program of transcriptional regulation of influenza-specific CD8
T
cells. We have previously demonstrated that the transcription factors Hobit and Blimp-1 are essential for the formation of CD8
T
cells across several tissues, including skin, liver, kidneys, and the small intestine. Here, we addressed the roles of Hobit and Blimp-1 in CD8
T
cell differentiation in the lungs after influenza infection using mice deficient for these transcription factors. Hobit was not required for the formation of influenza-specific CD8
T
cells in the lungs. In contrast, Blimp-1 was essential for the differentiation of lung CD8
T
cells and inhibited the differentiation of central memory CD8
T (T
) cells. We conclude that Blimp-1 rather than Hobit mediates the formation of CD8
T
cells in the lungs, potentially through control of the lineage choice between T
and T
cells during the differentiation of influenza-specific CD8
T cells.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
