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Prediction of psychosis: setting the stage
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Journal Article
Prediction of psychosis: setting the stage
2007
Overview
Treating psychotic disorders in their earliest stages has become a key focus
for research and clinical care. This paper reviews evidence of the capacity
to identify those at increased risk for psychotic disorder and to intervene
in the identified, high-risk individuals to ameliorate the course of
disorder. Issues involved in preventive oriented clinical care are
addressed, such as risk/benefit considerations, ethical and safety issues
and the value of stage-specific interventions. Clinical predictors
identified in recent research, promising intervention trials and proposed
clinical practice guidelines are described. An approach based on active
engagement, support and monitoring, yet with a conservative approach to
medication use is advocated at present. Potential neurobiological processes
have been studied and reinforce the sense that this is a critical phase for
active treatment, and may prove helpful in understanding the process of
transition across stages of illness. More research is required in
prediction, neurobiology and treatment
Publisher
Cambridge University Press,RCP
Subject
