Journal Article

Woven Endobridge Embolization Versus Microsurgical Clipping for Unruptured Anterior Circulation Aneurysms: A Propensity Score Analysis

Krischek, Boris, Kabbasch, Christoph, Schlamann, Marc, Goldbrunner, Roland, Siebert, Eberhard, Timmer, Marco, Liebig, Thomas, Laukamp, Kai Roman, Pennig, Lenhard, Goertz, Lukas, Dorn, Franziska, Celik, Erkan, Brinker, Gerrit

2021

Overview

Abstract BACKGROUND Intrasaccular flow-disruption represents a new paradigm in endovascular treatment of wide-necked bifurcation aneurysms. OBJECTIVE To retrospectively compare Woven Endobridge (WEB) embolization with microsurgical clipping for unruptured anterior circulation aneurysms using propensity score adjustment. METHODS A total of 63 patients treated with WEB and 103 patients treated with clipping were compared based on the intention-to-treat principle. The primary outcome measures were immediate technical treatment success, major adverse events, and 6-mo complete aneurysm occlusion. RESULTS The technical success rates were 83% for WEB and 100% for clipping. Procedure-related complications occurred more often in the clipping group (13%) than the WEB group (6%, adjusted P < .01). However, the rates of major adverse events were comparable in both groups (WEB: 3%, clip: 4%, adjusted P = .53). At the 6-mo follow-up, favorable functional outcomes were achieved in 98% of the WEB embolization group and 99% of the clipping group (adjusted P = .19). Six-month complete aneurysm occlusion was obtained in 75% of the WEB group and 94% of the clipping group (adjusted P < .01). CONCLUSION Microsurgical clipping was associated with higher technical success and complete occlusion rates, whereas WEB had a lower complication rate. Favorable functional outcomes were achieved in ≥98% of both groups. The decision to use a specific treatment modality should be made on an individual basis and in accordance with the patient's preferences. Graphical Abstract Graphical Abstract

• Publisher: Oxford University Press,Wolters Kluwer Health, Inc
• Subject: Adult / Aged / Aneurysms / Care and treatment / Carotid arteries / Clopidogrel / Comparative analysis / Drug dosages / Embolization / Embolization, Therapeutic - instrumentation / Embolization, Therapeutic - methods / Endovascular Procedures - instrumentation / Endovascular Procedures - methods / Female / Follow-Up Studies / Humans / Intracranial Aneurysm - diagnostic imaging / Intracranial Aneurysm - therapy / Male / Medical imaging / Microsurgery - instrumentation / Microsurgery - methods / Middle Aged / Morphology / Mortality / Neurosurgery / Patients / Propensity Score / Retrospective Studies / Self Expandable Metallic Stents / Stroke / Surgical Instruments / Treatment Outcome